TRDAHIGH SIGNALFINANCIAL10-K

TRDA experienced a dramatic financial deterioration with revenue collapsing 87.9% from $210.8M to $25.4M and swinging from $47M operating income to a $157.9M operating loss.

This represents a fundamental shift in the company's financial profile, suggesting either the loss of a major revenue source or completion of a significant one-time transaction in the prior year. The magnitude of these changes indicates potential business model disruption or major operational restructuring that investors need to investigate immediately.

Comparing 2026-02-26 vs 2025-02-27View on EDGAR →
FINANCIAL ANALYSIS

TRDA's financials show severe deterioration across all key metrics, with revenue plummeting 87.9% and the company swinging from profitability to massive losses, including a $157.9M operating loss and $143.8M net loss. Operating cash flow burn more than tripled to -$128.5M while the balance sheet contracted significantly, with current assets falling 30.4% to $306.3M and stockholders' equity declining 28.6%. Despite the reduced liabilities, this financial profile suggests a biotech company that likely completed a major partnership or licensing deal in the prior year and has now returned to typical R&D cash burn mode, raising questions about runway and future funding needs.

FINANCIAL STATEMENT CHANGES
Operating Income
P&L
-435.9%
$47.0M-$157.9M

Operating income deteriorated sharply — investigate whether driven by one-time charges or structural cost issues.

Net Income
P&L
-319%
$65.6M-$143.8M

Net income declined 319% — review whether driven by operations, interest costs, or non-recurring items.

Operating Cash Flow
Cash Flow
-209.2%
-$41.6M-$128.5M

Operating cash flow fell 209.2% — earnings quality concerns; investigate working capital changes and non-cash items.

Revenue
P&L
-87.9%
$210.8M$25.4M

Revenue declined 87.9% — significant demand weakness or market share loss warrants investigation.

Capital Expenditure
Cash Flow
-67%
$3.2M$1.0M

Capex reduced 67% — investment cycle winding down or capital discipline; may improve near-term free cash flow.

Current Liabilities
Balance Sheet
-38.1%
$39.5M$24.5M

Current liabilities reduced — improved short-term financial position and working capital health.

Current Assets
Balance Sheet
-30.4%
$440.0M$306.3M

Current assets declined 30.4% — monitor working capital adequacy and short-term liquidity.

Stockholders Equity
Balance Sheet
-28.6%
$428.7M$306.1M

Equity decreased 28.6% — buybacks or losses reducing book value, monitor solvency ratios.

Total Assets
Balance Sheet
-28.3%
$526.3M$377.4M

Total assets contracted 28.3% — asset sales, write-downs, or balance sheet optimization underway.

Total Liabilities
Balance Sheet
-27%
$97.6M$71.2M

Liabilities reduced 27% — deleveraging improves balance sheet strength and financial flexibility.

LANGUAGE CHANGES
NEW — 2026-02-26
PRIOR — 2025-02-27
ADDED
As of February 19, 2026, the registrant had 38,284,313 shares of common stock, $0.0001 par value per share, outstanding.
Form 10-K Summary 158 Signatures 159 From time to time, we may use our website or our LinkedIn profile at www.linkedin.com/company/entradatx to distribute material information.
federal government shutdown or reduced resources, new or increased international tariffs and retaliatory tariffs, trade protection measures, military conflicts, economic sanctions and economic slowdowns or recessions that may result from such developments which could harm our research and development efforts as well as the value of our common stock and our ability to access capital markets; other risks and uncertainties, including those listed under the caption Risk Factors.
Our estimates of the potential market opportunities for our product candidates include several key assumptions based on our industry knowledge, industry publications, third-party research, and other surveys, which may be based on a small sample size and may fail to accurately reflect market opportunities.
Through proprietary, versatile and modular approaches, we are advancing a robust development portfolio of genetic medicines for the potential treatment of neuromuscular and inherited retinal diseases, among others.
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REMOVED
As of February 20, 2025, the registrant had 37,594,630 shares of common stock, $0.0001 par value per share, outstanding.
Form 10-K Summary 156 Signatures 157 From time to time, we may use our website or our LinkedIn profile at www.linkedin.com/company/entradatx to distribute material information.
Industry publications and third-party research, surveys, and studies generally indicate that their information has been obtained from sources believed to be reliable, although they do not guarantee the accuracy or completeness of such information.
We enter 2025 with significant momentum, including the planned initiation of our next clinical trial of ENTR-601-44, regulatory submissions under review for ENTR-601-45, and the ongoing progress of our VX-670 partnership with Vertex Pharmaceuticals Incorporated ( Vertex ).
We plan to have four clinical programs in patients ongoing by the end of 2025, marking a new phase in the Company s growth.
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