TRDAHIGH SIGNALFINANCIAL10-K

TRDA experienced a dramatic revenue collapse while maintaining high R&D spending, indicating a significant shift from a revenue-generating phase back to a development-stage biotech model.

The substantial revenue decline suggests the end of a major partnership agreement or milestone payment cycle, which is common for biotech companies transitioning between development phases. Despite this revenue drop, the company maintained its R&D investment trajectory with meaningfully higher spending, indicating continued commitment to its clinical pipeline development.

Comparing 2026-02-26 vs 2025-02-27View on EDGAR →
FINANCIAL ANALYSIS

The company's financial profile shifted dramatically with revenue falling substantially while R&D expenses grew meaningfully to $142.3M, creating a challenging cash burn dynamic. The balance sheet contracted proportionally across most categories, with total assets declining 28% to $377.4M and stockholders' equity falling to $306.1M, though cash reserves remained relatively stable at $90.4M. This pattern suggests a biotech company consuming capital to fund development activities after the conclusion of major partnership revenues.

FINANCIAL STATEMENT CHANGES
Revenue
P&L
-87.9%
$210.8M$25.4M

Revenue declined 87.9% — significant demand weakness or market share loss warrants investigation.

Capital Expenditure
Cash Flow
-67%
$3.2M$1.0M

Capex reduced 67% — investment cycle winding down or capital discipline; may improve near-term free cash flow.

Current Liabilities
Balance Sheet
-38.1%
$39.5M$24.5M

Current liabilities reduced — improved short-term financial position and working capital health.

Current Assets
Balance Sheet
-30.4%
$440.0M$306.3M

Current assets declined 30.4% — monitor working capital adequacy and short-term liquidity.

Stockholders Equity
Balance Sheet
-28.6%
$428.7M$306.1M

Equity decreased 28.6% — buybacks or losses reducing book value, monitor solvency ratios.

Total Assets
Balance Sheet
-28.3%
$526.3M$377.4M

Total assets contracted 28.3% — asset sales, write-downs, or balance sheet optimization underway.

Total Liabilities
Balance Sheet
-27%
$97.6M$71.2M

Liabilities reduced 27% — deleveraging improves balance sheet strength and financial flexibility.

R&D Expense
P&L
+13.5%
$125.3M$142.3M

R&D investment increased 13.5% — signals commitment to future product development, though near-term margin impact.

Cash & Equivalents
Balance Sheet
-10.7%
$101.2M$90.4M

Cash decreased 10.7% — monitor burn rate and upcoming capital needs.

LANGUAGE CHANGES
NEW — 2026-02-26
PRIOR — 2025-02-27
ADDED
As of February 19, 2026, the registrant had 38,284,313 shares of common stock, $0.0001 par value per share, outstanding.
Form 10-K Summary 158 Signatures 159 From time to time, we may use our website or our LinkedIn profile at www.linkedin.com/company/entradatx to distribute material information.
federal government shutdown or reduced resources, new or increased international tariffs and retaliatory tariffs, trade protection measures, military conflicts, economic sanctions and economic slowdowns or recessions that may result from such developments which could harm our research and development efforts as well as the value of our common stock and our ability to access capital markets; other risks and uncertainties, including those listed under the caption Risk Factors.
Our estimates of the potential market opportunities for our product candidates include several key assumptions based on our industry knowledge, industry publications, third-party research, and other surveys, which may be based on a small sample size and may fail to accurately reflect market opportunities.
Through proprietary, versatile and modular approaches, we are advancing a robust development portfolio of genetic medicines for the potential treatment of neuromuscular and inherited retinal diseases, among others.
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REMOVED
As of February 20, 2025, the registrant had 37,594,630 shares of common stock, $0.0001 par value per share, outstanding.
Form 10-K Summary 156 Signatures 157 From time to time, we may use our website or our LinkedIn profile at www.linkedin.com/company/entradatx to distribute material information.
Industry publications and third-party research, surveys, and studies generally indicate that their information has been obtained from sources believed to be reliable, although they do not guarantee the accuracy or completeness of such information.
We enter 2025 with significant momentum, including the planned initiation of our next clinical trial of ENTR-601-44, regulatory submissions under review for ENTR-601-45, and the ongoing progress of our VX-670 partnership with Vertex Pharmaceuticals Incorporated ( Vertex ).
We plan to have four clinical programs in patients ongoing by the end of 2025, marking a new phase in the Company s growth.
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