SYREMEDIUM SIGNALFINANCIAL10-K

SYRE significantly strengthened its balance sheet with stockholders' equity increasing 38.1% to $715.2M while reducing total liabilities by 31%, though the company continues burning substantial cash with a $155.2M net loss.

The substantial increase in stockholders' equity combined with reduced liabilities suggests SYRE completed a significant financing round or equity raise, providing crucial runway for this clinical-stage biotech company. While the company reduced its net loss by 25.4% year-over-year, it's still burning over $150M annually, making the improved capital position critical for funding ongoing clinical operations.

Comparing 2026-02-19 vs 2025-02-27View on EDGAR →
FINANCIAL ANALYSIS

SYRE's financial position improved markedly with stockholders' equity jumping 38.1% to $715.2M and total liabilities declining 31% to $62.5M, resulting in total assets growing 27.8% to $777.8M. The company reduced its net loss from $208.0M to $155.2M, representing a 25.4% improvement in cash burn efficiency. Overall, this signals a biotech company that has successfully raised capital to fund operations while demonstrating some progress in managing expenses, though substantial cash burn continues as expected for a clinical-stage company.

FINANCIAL STATEMENT CHANGES
Stockholders Equity
Balance Sheet
+38.1%
$517.8M$715.2M

Equity base grew 38.1% — retained earnings accumulation or equity issuance strengthening the balance sheet.

Total Liabilities
Balance Sheet
-31%
$90.7M$62.5M

Liabilities reduced 31% — deleveraging improves balance sheet strength and financial flexibility.

Total Assets
Balance Sheet
+27.8%
$608.5M$777.8M

Asset base grew 27.8% — expansion through organic growth, acquisitions, or capital deployment.

Current Assets
Balance Sheet
+27.8%
$608.5M$777.8M

Current assets grew 27.8% — improving short-term liquidity or inventory/receivables build.

Net Income
P&L
+25.4%
-$208.0M-$155.2M

Net income grew 25.4% — bottom-line growth signals improving overall business health.

LANGUAGE CHANGES
NEW — 2026-02-19
PRIOR — 2025-02-27
ADDED
Unless the context indicates otherwise, as used in this Annual Report, the terms Spyre, "Aeglea BioTherapeutics, Inc.," "Aeglea," the Company, we, us, and our refer to Spyre Therapeutics, Inc., a Delaware corporation, and its consolidated subsidiaries taken as a whole.
(NASDAQ: SYRE) is a clinical-stage biotechnology company pioneering long-acting antibodies and antibody combinations to redefine the standard of care for inflammatory bowel disease ( IBD ) and rheumatic diseases.
Combined, these attributes have the potential to enable quarterly or twice annual subcutaneous ("SC") maintenance dosing, and have upside potential to increase or accelerate efficacy via increasing PK exposures, based on published exposure-response or dose-response relationships for each mechanism in IBD.
Potency of SPY001, SPY002, and SPY003 compared to first-generation in-class molecules Source: Data on file.
Potency refers to in vitro potency: SPY001 assay reports inhibition of cells expressing a4b7 binding to MAdCAM-1.
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REMOVED
Although we believe that the expectations reflected in the forward-looking statements are reasonable, we cannot guarantee that the future results, levels of activity, performance or events and circumstances reflected in the forward-looking statements will be achieved or occur.
(NASDAQ: SYRE) is a clinical-stage biotechnology company utilizing potential best-in-class antibody engineering, dose optimization, and rational therapeutic combinations to target improved efficacy and convenience in the treatment of IBD and other immune-mediated diseases.
Combined, these attributes have the potential to enable infrequent subcutaneous ("SC") maintenance dosing compared to competitor molecules, and have upside potential to increase or accelerate efficacy via increasing PK exposures, based on published exposure-response or dose-response relationships for each mechanism in IBD.
Anti-TL1A indication expansion TL1A has been implicated in a wide range of human diseases beyond IBD based on genetic, translational, and/or preclinical data, including diseases within but not limited to: RA, axial spondyloarthritis, psoriatic arthritis, systemic sclerosis-interstitial lung disease, asthma, pulmonary sarcoidosis, psoriasis, hidradentis suppurativa, and atopic dermatitis.
Inflammatory Bowel Disease IBD is a chronic condition characterized by inflammation within the gastrointestinal tract.
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