SLXNMEDIUM SIGNALFINANCIAL10-K

Silexion Therapeutics shows improved net loss performance and reduced liabilities, though operating cash burn worsened and R&D spending increased as the company advances its pancreatic cancer treatment pipeline.

The company demonstrated better bottom-line performance with meaningfully reduced net losses while maintaining increased investment in R&D activities for its lead siRNA candidate SIL204. The reduction in total liabilities alongside higher operating cash burn suggests the company is managing its balance sheet while investing in clinical development, though cash consumption remains a key monitoring point for this biotechnology firm.

Comparing 2026-03-17 vs 2025-03-18View on EDGAR →
FINANCIAL ANALYSIS

The financial picture shows mixed signals with net losses improving substantially while operating cash flow deteriorated and R&D expenses grew notably by 22.8%. Total liabilities declined meaningfully by $2.3M, indicating improved balance sheet management, though the company continues to burn cash at an elevated rate of $10.8M from operations. The overall trajectory suggests active clinical-stage operations with better expense management translating to reduced net losses despite higher research spending.

FINANCIAL STATEMENT CHANGES
Capital Expenditure
Cash Flow
-59.1%
$22K$9K

Capex reduced 59.1% — investment cycle winding down or capital discipline; may improve near-term free cash flow.

Total Liabilities
Balance Sheet
-32.7%
$6.9M$4.6M

Liabilities reduced 32.7% — deleveraging improves balance sheet strength and financial flexibility.

Operating Cash Flow
Cash Flow
-28.9%
-$8.4M-$10.8M

Operating cash flow softened — monitor whether temporary working capital timing or structural deterioration.

Net Income
P&L
+27.9%
-$16.5M-$11.9M

Net income grew 27.9% — bottom-line growth signals improving overall business health.

R&D Expense
P&L
+22.8%
$5.8M$7.1M

R&D investment increased 22.8% — signals commitment to future product development, though near-term margin impact.

Current Liabilities
Balance Sheet
-21.7%
$3.5M$2.8M

Current liabilities reduced — improved short-term financial position and working capital health.

LANGUAGE CHANGES
NEW — 2026-03-17
PRIOR — 2025-03-18
ADDED
Silexion Therapeutics Corp - 2022416 - 2026 Represents an amount less than $1 Net of 28 treasury shares held by the Company as of December 31, 2024 false 0002022416 FY 00-0000000 Other segment expenses include mainly general and administrative-related expenses, such as rent and maintenance expenses, travel and HR expenses.
As of March 10, 2026, 3,330,785 ordinary shares, par value $0.0135 per share, were issued and outstanding.
Our approach targets a significant unmet medical need, as treatment innovation for KRAS-driven cancers has historically lagged despite KRAS being one of the most common oncogenic drivers across solid tumors.
Our lead product candidate, SIL204, consists of locally administered small interfering RNAs, or siRNA, in a solution as a first-line treatment of locally advanced pancreatic cancer patients, or LAPC, in combination with standard-of-care chemotherapy, and uses an integrated treatment approach that combines intratumoral and systemic administration.
We were formed through a business combination that was completed on August 15, 2024, when Silexion Therapeutics Corp (then known as Biomotion Sciences) consummated previously-announced transactions with Silexion Therapeutics Ltd.
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REMOVED
** Represents exercises of fully vested pre-funded options for the Company s ordinary shares at an exercise price of $0.0226 or 0.0226 NIS per share **** Net of 421 treasury shares held by the Company as of December 31, 2024 Leasehold improvements are amortized by the straight-line method over the expected lease term, which is shorter than the estimated useful life of the improvements.
As of March 1, 2025, 8,414,615 ordinary shares, par value $0.0009 per share, were issued and outstanding.
Our lead product candidate, SIL204, consists of locally administered small interfering RNAs, or siRNA, in a solution as a first-line treatment of locally advanced pancreatic cancer patients, or LAPC, in combination with standard-of-care chemotherapy.
On August 15, 2024, Silexion Therapeutics Corp (then known as Biomotion Sciences), a Cayman Islands exempted company ( New Silexion ), consummated the previously announced transactions pursuant to that certain Amended and Restated Business Combination Agreement, dated as of April 3, 2024 (as amended, the Business Combination Agreement ), by and among New Silexion, Moringa Acquisition Corp ( Moringa ), August M.S.
Ltd., an Israeli company and a wholly-owned subsidiary of New Silexion ( Merger Sub 1 ), Moringa Acquisition Merger Sub Corp, a Cayman Islands exempted company and a wholly-owned subsidiary of New Silexion ( Merger Sub 2 ), and Silexion Therapeutics Ltd., an Israeli company ( Silexion ).
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