RLAYMEDIUM SIGNALOPERATIONAL10-K

Relay Therapeutics has evolved from a computational drug discovery platform company to a focused clinical-stage precision medicine company with zovegalisib advancing to Phase 3 trials and receiving FDA Breakthrough Therapy designation.

This represents a significant strategic pivot from a technology-focused discovery platform to a traditional biotech with lead assets in late-stage development. The FDA Breakthrough Therapy designation for zovegalisib in HR+/HER2- breast cancer and initiation of the global Phase 3 ReDiscover-2 trial mark important clinical milestones that could accelerate the path to commercialization.

Comparing 2026-02-26 vs 2025-02-26View on EDGAR →
FINANCIAL ANALYSIS

The financial profile reflects a maturing clinical-stage biotech with revenue growing 53% to $15.4M while R&D expenses increased 42% to $99.9M as the company advances expensive Phase 3 trials. Cash declined 32% to $84.0M indicating significant cash burn, though the 50% reduction in current liabilities and 42% decrease in total liabilities suggests improved balance sheet management. Overall, the metrics show increased clinical investment funded by cash reserves and improved liability management, typical of a company transitioning to late-stage development.

FINANCIAL STATEMENT CHANGES
Capital Expenditure
Cash Flow
-79.7%
$2.0M$410K

Capex reduced 79.7% — investment cycle winding down or capital discipline; may improve near-term free cash flow.

Revenue
P&L
+53.4%
$10.0M$15.4M

Strong top-line growth of 53.4% — accelerating demand or successful expansion into new markets.

Current Liabilities
Balance Sheet
-49.6%
$50.7M$25.6M

Current liabilities reduced — improved short-term financial position and working capital health.

R&D Expense
P&L
+42%
$70.3M$99.9M

R&D investment increased 42% — signals commitment to future product development, though near-term margin impact.

Total Liabilities
Balance Sheet
-42%
$93.5M$54.3M

Liabilities reduced 42% — deleveraging improves balance sheet strength and financial flexibility.

Cash & Equivalents
Balance Sheet
-32.4%
$124.3M$84.0M

Cash declined 32.4% — significant cash burn or deployment; verify adequacy of remaining liquidity runway.

Total Assets
Balance Sheet
-28.7%
$871.3M$621.3M

Total assets contracted 28.7% — asset sales, write-downs, or balance sheet optimization underway.

Current Assets
Balance Sheet
-28.5%
$809.2M$578.3M

Current assets declined 28.5% — monitor working capital adequacy and short-term liquidity.

Stockholders Equity
Balance Sheet
-27.1%
$777.8M$567.1M

Equity decreased 27.1% — buybacks or losses reducing book value, monitor solvency ratios.

Accounts Receivable
Balance Sheet
-24.1%
$403K$306K

Receivables declined — improved collection efficiency or conservative revenue recognition.

LANGUAGE CHANGES
NEW — 2026-02-26
PRIOR — 2025-02-26
ADDED
10-K 414 false 0001812364 389 FY 386 350 http://fasb.org/us-gaap/2025#LicenseAndServiceMember http://fasb.org/us-gaap/2025#LicenseAndServiceMember http://fasb.org/us-gaap/2025#LicenseAndServiceMember http://relaytx.com/20251231#PresidentAndChiefExecutiveOfficerMember http://relaytx.com/20251231#PresidentAndChiefExecutiveOfficerMember http://fasb.org/us-gaap/2025#LicenseAndServiceMember http://fasb.org/us-gaap/2025#LicenseAndServiceMember http://fasb.org/us-gaap/2025#LicenseAndServiceMember On June 3, 2025, the Company and ARE MA Region No.
Overview We are a clinical-stage, small molecule precision medicine company developing potentially life-changing therapies for patients living with cancer and genetic disease.
We are also advancing triplet combination arms with zovegalisib, fulvestrant and cyclin dependent kinase 4/6, or CDK 4/6, inhibitors, or atirmociclib, the investigative selective-CDK4 inhibitor from Pfizer Inc., or Pfizer.
In the second quarter of 2025, we initiated a global Phase 3 registrational study, or the ReDiscover-2 Trial, which is designed to evaluate the safety and efficacy of zovegalisib plus fulvestrant in PI3K -mutated, HR+/HER2- advanced breast cancer patients previously treated with a CDK4/6 inhibitor.
The comparator arm in the ReDiscover-2 Trial is capivasertib plus fulvestrant.
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REMOVED
Overview We are a clinical-stage precision medicine company transforming the drug discovery process by combining leading-edge computational and experimental technologies with the goal of bringing life-changing therapies to patients.
As we believe we are among the first of a new breed of biotech created at the intersection of complementary techniques and technologies, we aim to push the boundaries of what s possible in drug discovery.
Our initial focus is on enhancing small molecule therapeutic discovery in targeted oncology and genetic disease indications.
In the fourth quarter of 2023, we initiated a triplet combination arm with RLY-2608, fulvestrant and the cyclin dependent kinase 4/6, or CDK 4/6, inhibitor ribociclib.
In the fourth quarter of 2024, we initiated an additional triplet combination arm with RLY-2608, fulvestrant, and atirmociclib, Pfizer Inc.
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