PRTAHIGH SIGNALFINANCIAL10-K

PRTA's net losses substantially increased while the company burned through nearly $164 million in cash during the year, reducing its financial runway significantly.

The company's losses roughly doubled year-over-year despite meaningfully lower R&D spending, indicating potential operational inefficiencies or one-time charges that warrant investigation. With cash reserves declining from $471M to $308M and minimal revenue generation, PRTA faces mounting pressure to achieve meaningful clinical milestones or secure additional funding to sustain operations.

Comparing 2026-02-27 vs 2025-02-27View on EDGAR →
FINANCIAL ANALYSIS

PRTA experienced a challenging financial year with losses substantially increasing while R&D expenses declined by nearly 40%, suggesting the higher losses stem from factors beyond core research spending. The company's balance sheet weakened considerably with total assets falling from $547M to $327M, driven primarily by the significant cash burn that reduced liquidity by over $160M. Despite lower liabilities providing some relief, the combination of dramatically higher losses and substantial cash depletion signals heightened financial stress for this biotech company.

FINANCIAL STATEMENT CHANGES
Net Income
P&L
-99.6%
-$122.3M-$244.1M

Net income declined 99.6% — review whether driven by operations, interest costs, or non-recurring items.

Stockholders Equity
Balance Sheet
-42.4%
$486.9M$280.5M

Equity declined sharply — large losses, buybacks, or write-downs reducing book value significantly.

Total Assets
Balance Sheet
-40.3%
$547.1M$326.8M

Total assets contracted 40.3% — asset sales, write-downs, or balance sheet optimization underway.

R&D Expense
P&L
-39.4%
$222.5M$134.9M

R&D spending cut 39.4% — could signal cost discipline or concerning reduction in innovation investment.

Operating Income
P&L
-38.9%
-$154.6M-$214.6M

Operating income deteriorated sharply — investigate whether driven by one-time charges or structural cost issues.

Current Assets
Balance Sheet
-35.1%
$485.4M$315.2M

Current assets declined 35.1% — monitor working capital adequacy and short-term liquidity.

Cash & Equivalents
Balance Sheet
-34.8%
$471.4M$307.5M

Cash declined 34.8% — significant cash burn or deployment; verify adequacy of remaining liquidity runway.

Total Liabilities
Balance Sheet
-23%
$60.2M$46.3M

Liabilities reduced 23% — deleveraging improves balance sheet strength and financial flexibility.

Current Liabilities
Balance Sheet
-15.8%
$48.5M$40.8M

Current liabilities reduced — improved short-term financial position and working capital health.

Revenue
P&L
-14.8%
$955K$814K

Revenue softened 14.8% — monitor whether this is cyclical or structural.

LANGUAGE CHANGES
NEW — 2026-02-27
PRIOR — 2025-02-27
ADDED
53,832,982 of the Registrant s ordinary shares, par value $0.01 per share, were outstand ing as of February 20, 2026.
The Company s pipeline includes both wholly-owned and partnered programs being developed for the potential treatment of diseases including Parkinson s disease, ATTR amyloidosis with cardiomyopathy, Alzheimer s disease, Amyotrophic lateral sclerosis (ALS) and a number of other neurodegenerative diseases.
Prothena is developing and applying its proprietary CYTOPE technology to target a broad spectrum of intracellular disease pathways in the brain and periphery.
Transthyretin amyloidosis (ATTR amyloidosis) is a rare, progressive and fatal disease characterized by deposition of aggregated misfolded transthyretin proteins in vital organs such as the heart.
It is believed two different proteins A (amyloid beta) and tau are important contributors to Alzheimer s disease pathology.
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REMOVED
53,826,982 of the Registrant s ordinary shares, par value $0.01 per share, were outstand ing as of February 20, 2025 .
Our wholly-owned programs include birtamimab for the potential treatment of AL amyloidosis, and a portfolio of programs for the potential treatment of Alzheimer s disease including PRX012, which targets amyloid beta (A ), and PRX123, a novel dual A -tau vaccine.
Our partnered programs include prasinezumab for the potential treatment of Parkinson s disease and other related synucleinopathies that targets alpha-synuclein in collaboration with Roche.
In addition, we have partnered BMS-986446 (formerly PRX005) for the potential treatment of Alzheimer s disease that targets tau and PRX019 for the potential treatment of neurodegenerative diseases with an undisclosed target in two separate license agreements with Bristol Myers Squibb (BMS).
We are also entitled to certain potential milestone payments pursuant to the Company s share purchase agreement with Novo Nordisk pertaining to the Company s ATTR amyloidosis business (inclusive of coramitug, formerly PRX004).
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