PRTAHIGH SIGNALFINANCIAL10-K

Prothena experienced severe financial deterioration with net losses doubling to $244M while burning through $164M in cash, reducing stockholders' equity by 42% and total assets by 40%.

The company is experiencing a significant cash burn crisis that threatens its financial sustainability, with stockholders' equity declining from $487M to $281M in just one year. While R&D expenses decreased 39%, this wasn't enough to offset the massive increase in net losses, suggesting either substantial one-time charges or operational inefficiencies that require immediate investor attention.

Comparing 2026-02-27 vs 2025-02-27View on EDGAR →
FINANCIAL ANALYSIS

Despite reducing R&D spending by $88M (-39%), Prothena's net losses nearly doubled from $122M to $244M, indicating significant non-operational charges or expenses. The company burned through $164M in cash while total assets declined 40% and stockholders' equity fell 42%, creating a concerning financial trajectory. The modest revenue increase to $814K provides little relief against the massive loss expansion, signaling potential liquidity concerns if the current burn rate continues.

FINANCIAL STATEMENT CHANGES
Revenue
P&L
+297.1%
$205K$814K

Strong top-line growth of 297.1% — accelerating demand or successful expansion into new markets.

Net Income
P&L
-99.6%
-$122.3M-$244.1M

Net income declined 99.6% — review whether driven by operations, interest costs, or non-recurring items.

Stockholders Equity
Balance Sheet
-42.4%
$486.9M$280.5M

Equity declined sharply — large losses, buybacks, or write-downs reducing book value significantly.

Total Assets
Balance Sheet
-40.3%
$547.1M$326.8M

Total assets contracted 40.3% — asset sales, write-downs, or balance sheet optimization underway.

R&D Expense
P&L
-39.4%
$222.5M$134.9M

R&D spending cut 39.4% — could signal cost discipline or concerning reduction in innovation investment.

Operating Income
P&L
-38.9%
-$154.6M-$214.6M

Operating income deteriorated sharply — investigate whether driven by one-time charges or structural cost issues.

Current Assets
Balance Sheet
-35.1%
$485.4M$315.2M

Current assets declined 35.1% — monitor working capital adequacy and short-term liquidity.

Cash & Equivalents
Balance Sheet
-34.8%
$471.4M$307.5M

Cash declined 34.8% — significant cash burn or deployment; verify adequacy of remaining liquidity runway.

Total Liabilities
Balance Sheet
-23%
$60.2M$46.3M

Liabilities reduced 23% — deleveraging improves balance sheet strength and financial flexibility.

Current Liabilities
Balance Sheet
-15.8%
$48.5M$40.8M

Current liabilities reduced — improved short-term financial position and working capital health.

LANGUAGE CHANGES
NEW — 2026-02-27
PRIOR — 2025-02-27
ADDED
53,832,982 of the Registrant s ordinary shares, par value $0.01 per share, were outstand ing as of February 20, 2026.
The Company s pipeline includes both wholly-owned and partnered programs being developed for the potential treatment of diseases including Parkinson s disease, ATTR amyloidosis with cardiomyopathy, Alzheimer s disease, Amyotrophic lateral sclerosis (ALS) and a number of other neurodegenerative diseases.
Prothena is developing and applying its proprietary CYTOPE technology to target a broad spectrum of intracellular disease pathways in the brain and periphery.
Transthyretin amyloidosis (ATTR amyloidosis) is a rare, progressive and fatal disease characterized by deposition of aggregated misfolded transthyretin proteins in vital organs such as the heart.
It is believed two different proteins A (amyloid beta) and tau are important contributors to Alzheimer s disease pathology.
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REMOVED
53,826,982 of the Registrant s ordinary shares, par value $0.01 per share, were outstand ing as of February 20, 2025 .
Our wholly-owned programs include birtamimab for the potential treatment of AL amyloidosis, and a portfolio of programs for the potential treatment of Alzheimer s disease including PRX012, which targets amyloid beta (A ), and PRX123, a novel dual A -tau vaccine.
Our partnered programs include prasinezumab for the potential treatment of Parkinson s disease and other related synucleinopathies that targets alpha-synuclein in collaboration with Roche.
In addition, we have partnered BMS-986446 (formerly PRX005) for the potential treatment of Alzheimer s disease that targets tau and PRX019 for the potential treatment of neurodegenerative diseases with an undisclosed target in two separate license agreements with Bristol Myers Squibb (BMS).
We are also entitled to certain potential milestone payments pursuant to the Company s share purchase agreement with Novo Nordisk pertaining to the Company s ATTR amyloidosis business (inclusive of coramitug, formerly PRX004).
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