PHIOHIGH SIGNALFINANCIAL10-K

PHIO experienced a dramatic improvement in financial position with stockholders' equity surging 327% to $20.1M and cash increasing 291% to $21.0M, likely from equity financing, though operating losses deepened to $9.2M.

The massive increase in cash and equity suggests PHIO completed a significant capital raise, providing substantial runway for operations and clinical trials. However, the 25% increase in operating losses to $9.2M indicates accelerating cash burn that could offset the benefits of the new capital if not managed effectively.

Comparing 2026-03-05 vs 2025-03-31View on EDGAR →
FINANCIAL ANALYSIS

PHIO's balance sheet was dramatically strengthened with stockholders' equity jumping 327% to $20.1M and cash surging 291% to $21.0M, while current liabilities decreased 38%, indicating a major capital infusion likely through equity financing. However, the income statement deteriorated with R&D expenses rising 27% to $4.6M and operating losses widening 25% to $9.2M, reflecting increased clinical trial activity and operational costs. The overall picture shows a biotech company that has secured significant funding but is experiencing accelerating cash burn as it advances its pipeline.

FINANCIAL STATEMENT CHANGES
Capital Expenditure
Cash Flow
+1100%
$1K$12K

Capital expenditure jumped 1100% — major investment cycle underway; assess returns on deployment.

Stockholders Equity
Balance Sheet
+326.6%
$4.7M$20.1M

Equity base grew 326.6% — retained earnings accumulation or equity issuance strengthening the balance sheet.

Cash & Equivalents
Balance Sheet
+290.8%
$5.4M$21.0M

Cash position surged 290.8% — strong cash generation or capital raise providing significant financial cushion.

Total Assets
Balance Sheet
+274.5%
$5.7M$21.5M

Asset base grew 274.5% — expansion through organic growth, acquisitions, or capital deployment.

Current Assets
Balance Sheet
+274.4%
$5.7M$21.5M

Current assets grew 274.4% — improving short-term liquidity or inventory/receivables build.

Current Liabilities
Balance Sheet
-37.9%
$1.6M$1.0M

Current liabilities reduced — improved short-term financial position and working capital health.

Total Liabilities
Balance Sheet
+32%
$1.0M$1.3M

Liabilities grew 32% — significant increase in debt or obligations, assess impact on financial flexibility.

R&D Expense
P&L
+26.8%
$3.6M$4.6M

R&D investment increased 26.8% — signals commitment to future product development, though near-term margin impact.

Operating Income
P&L
-24.8%
-$7.4M-$9.2M

Operating profitability softening — costs rising faster than revenue, watch for margin recovery plan.

Net Income
P&L
-21.7%
-$7.2M-$8.7M

Net income declined 21.7% — review whether driven by operations, interest costs, or non-recurring items.

LANGUAGE CHANGES
NEW — 2026-03-05
PRIOR — 2025-03-31
ADDED
phio20251231_10k.htm 0001533040 Phio Pharmaceuticals Corp false --12-31 FY 2025 We maintain various information security processes to manage cybersecurity risks designed to support the security, reliability and resilience of our information systems.
This program includes a number of safeguards, such as: continuous monitoring for internal and external threats, periodic evaluations of our cybersecurity program, including external reviews, benchmarking against industry standards and practices, periodic penetration testing and phishing simulations and cybersecurity awareness training for all employees.
true true true Although we have experienced phishing attempts during the past three years, we have not experienced any cybersecurity threats or incidents that have materially affected our business strategy, results of operations or financial condition nor are we aware of any such risks that are reasonably likely to have such a material effect.
Cybersecurity incidents and threats continue to evolve, and despite our safeguards, we may not be able to anticipate, detect or prevent threats in a timely manner.
For additional information, see Item 1A Risk Factors- Our business and operations would suffer in the event of a cybersecurity incident.
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REMOVED
As of March 20, 2025 the registrant had 4,778,154 shares of Common Stock outstanding.
The Company operates with a single operating segment and a single reporting segment the Clinical segment.
In May and December 2024, respectively, a Safety Monitoring Committee (SMC) reviewed data from the first and second dose cohorts treated with PH-762, and in both instances recommended escalation to the next dose concentration.
A total of 7 patients with cutaneous carcinomas have been enrolled in dose cohorts 1 and 2.
The second cohort enrolled a total of 4 patients who were diagnosed with cutaneous squamous cell carcinoma.
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