NKTRHIGH SIGNALFINANCIAL10-K

NKTR shows a dramatic 85% reduction in outstanding shares (from 186M to 29M shares) alongside severe cash burn and deteriorating operations despite doubled revenue.

The massive share reduction suggests a significant corporate restructuring event such as a reverse stock split, while the company burned through 66% of its cash reserves despite revenue doubling. The combination of operational losses widening and critical dependence on Eli Lilly's cooperation for key drug development creates substantial execution risk for investors.

Comparing 2026-03-13 vs 2025-03-14View on EDGAR →
FINANCIAL ANALYSIS

Revenue doubled to $308M but gross profit collapsed 76% to just $623K, indicating severely deteriorated margins, while net losses widened 38% to $164M and operating cash flow deteriorated to -$209M. Cash reserves plummeted 66% to only $15M while stockholders' equity paradoxically increased 48% to $90M, likely due to the dramatic share count reduction. The overall picture signals a company struggling with profitability and cash management despite top-line growth, creating immediate liquidity concerns.

FINANCIAL STATEMENT CHANGES
Revenue
P&L
+101.2%
$152.9M$307.7M

Strong top-line growth of 101.2% — accelerating demand or successful expansion into new markets.

Capital Expenditure
Cash Flow
-88.4%
$1.5M$171K

Capex reduced 88.4% — investment cycle winding down or capital discipline; may improve near-term free cash flow.

Gross Profit
P&L
-76.4%
$2.6M$623K

Gross margin compression — rising input costs, pricing pressure, or unfavorable product mix shift.

Cash & Equivalents
Balance Sheet
-65.8%
$44.3M$15.1M

Cash declined 65.8% — significant cash burn or deployment; verify adequacy of remaining liquidity runway.

Stockholders Equity
Balance Sheet
+47.9%
$60.7M$89.8M

Equity base grew 47.9% — retained earnings accumulation or equity issuance strengthening the balance sheet.

Net Income
P&L
-37.9%
-$119.0M-$164.1M

Net income declined 37.9% — review whether driven by operations, interest costs, or non-recurring items.

Operating Income
P&L
-33.2%
-$105.2M-$140.1M

Operating income deteriorated sharply — investigate whether driven by one-time charges or structural cost issues.

Total Liabilities
Balance Sheet
-21.6%
$243.1M$190.6M

Liabilities reduced 21.6% — deleveraging improves balance sheet strength and financial flexibility.

Operating Cash Flow
Cash Flow
-18.7%
-$175.7M-$208.5M

Operating cash flow softened — monitor whether temporary working capital timing or structural deterioration.

Current Liabilities
Balance Sheet
-12.8%
$61.4M$53.5M

Current liabilities reduced — improved short-term financial position and working capital health.

LANGUAGE CHANGES
NEW — 2026-03-13
PRIOR — 2025-03-14
ADDED
As of March 11, 2026, the number of outstanding shares of the registrant s com mon stock was 28,687,963 .
Such Proxy Statement will be filed with the Securities and Exchange Commission within 120 days of the end of the fiscal year covered by this Annual Report on Form 10-K.
o while we believe we currently have the documents, records and data that are necessary for us to continue clinical development of rezpegaldesleukin, our ability to perform important development and regulatory activities will be significantly harmed if Eli Lilly and Company fails to continue to cooperate with us in the transfer of all documents, records and data associated with the rezpegaldesleukin program.
Risks Related to Intellectual Property, Litigation and Regulatory Concerns: o we or our partners may not obtain regulatory approval for our drug candidates on a timely basis, or at all; o disruptions to the normal functioning of the U.S.
Our pipeline of clinical-stage and preclinical-stage immunomodulatory agents targets the treatment of autoimmune diseases (e.g., rezpegaldesleukin and NKTR-0165/0166, respectively) and cancer (e.g.
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REMOVED
As of March 6, 2025, the number of outstanding shares of the registrant s com mon stock was 186,103,588 .
Summary of R isks We are providing the following cautionary discussion of risk factors, uncertainties and assumptions that we believe are relevant to our business.
Risks Related to Supply and Manufacturing : o if our contract manufacturers are not able to manufacture drugs or drug substances in sufficient quantities that meet applicable quality standards, our business, financial condition and results of operations could be harmed; and o we purchase some of the starting material for drugs and drug candidates from a single source or a limited number of suppliers, and the partial or complete loss of one of these suppliers could cause delays, loss of revenue and contract liability.
Our pipeline of clinical-stage and preclinical-stage immunomodulatory agents targets the treatment of autoimmune diseases (e.g.
rezpegaldesleukin and NKTR-0165, respectively) and cancer (e.g.
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