KTTAHIGH SIGNALFINANCIAL10-K

KTTA completed a major equity financing that dramatically increased cash position to $55.2M while shifting strategic focus toward RASopathies and MAPK pathway-driven tumors as primary indications.

The massive increase in outstanding shares (from 2.7M to 24.9M plus 64M pre-funded warrants) indicates significant dilution from capital raising, but provides substantial runway for clinical development. The strategic pivot from CNS-focused to RASopathies-focused development suggests management is realigning resources toward higher-probability indications for their lead MEK inhibitor PAS-004.

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FINANCIAL ANALYSIS

KTTA's financial position was transformed through a major equity raise, with cash surging 697% to $55.2M and total assets growing 275% to $60.2M, providing significant clinical development runway. Despite minimal revenue growth to $487K, net losses deepened 47% to $20.4M reflecting increased R&D spending, while the 91% reduction in capex suggests focus shifted from infrastructure to clinical programs. The dramatic increase in share count combined with substantial cash infusion indicates heavy dilution but positions the company for extended operations without near-term funding concerns.

FINANCIAL STATEMENT CHANGES
Revenue
P&L
+3130.4%
$15K$487K

Strong top-line growth of 3130.4% — accelerating demand or successful expansion into new markets.

Cash & Equivalents
Balance Sheet
+696.8%
$6.9M$55.2M

Cash position surged 696.8% — strong cash generation or capital raise providing significant financial cushion.

Current Assets
Balance Sheet
+666.2%
$7.4M$56.5M

Current assets grew 666.2% — improving short-term liquidity or inventory/receivables build.

Current Liabilities
Balance Sheet
+344.2%
$1.1M$5.0M

Current liabilities surged 344.2% — significant near-term obligations; verify ability to meet short-term debt.

Total Liabilities
Balance Sheet
+291.6%
$1.3M$5.0M

Liabilities grew 291.6% — significant increase in debt or obligations, assess impact on financial flexibility.

Total Assets
Balance Sheet
+275%
$16.1M$60.2M

Asset base grew 275% — expansion through organic growth, acquisitions, or capital deployment.

Stockholders Equity
Balance Sheet
+273.5%
$14.8M$55.2M

Equity base grew 273.5% — retained earnings accumulation or equity issuance strengthening the balance sheet.

Capital Expenditure
Cash Flow
-90.9%
$375K$34K

Capex reduced 90.9% — investment cycle winding down or capital discipline; may improve near-term free cash flow.

Interest Expense
P&L
-79.9%
508102

Interest expense declined — debt repayment or refinancing at lower rates improving earnings quality.

Net Income
P&L
-46.9%
-$13.9M-$20.4M

Net income declined 46.9% — review whether driven by operations, interest costs, or non-recurring items.

LANGUAGE CHANGES
NEW — 2026-03-30
PRIOR — 2025-03-24
ADDED
As of March 24, 2026, there were 24,939,948 shares of the registrant s Common Stock outstanding.
This number does not include 64,053,335 shares of Common Stock issuable upon the exercise of pre-funded warrants outstanding as of March 24, 2026 (which are immediately exercisable at an exercise price of $0.001 per share of Common Stock, subject to beneficial ownership limitations).
You should review the factors and risks and other information we describe herein and in the other reports we file from time to time with the SEC (as defined below).
BUSINESS Overview We are a clinical-stage biotechnology company focused on the discovery, research and development of innovative treatments for RASopathies, MAPK pathway-driven tumors, and other diseases, including central nervous system (CNS) disorders.
Our Therapeutic Pipeline We are advancing a pipeline of two therapeutic product candidates, with a focus on our lead product candidate, PAS-004, a next-generation macrocyclic (as defined below) Mitogen-Activated Protein Kinase ( MEK ) inhibitor, that we believe may address the limitations and liabilities associated with existing drugs with a similar mechanism of action.
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REMOVED
As of March 20, 2025, there were 2,705,263 shares of the registrant s Common Stock outstanding.
You should review the factors and risks and other information we describe in the reports we will file from time to time with the SEC.
iii EXPLANATORY NOTE On December 28, 2023, our board of directors ( Board ) approved a 1:20 reverse stock split (the Reverse Stock Split ) of our outstanding shares of common stock, par value $0.0001 per share ( Common Stock ), which became effective on January 2, 2024.
In connection with the Reverse Stock Split, there was a corresponding reduction in the number of authorized shares of Common Stock to 100,000,000.
Unless otherwise noted, the share and per share information in this Annual Report on Form 10-K reflects the Reverse Stock Split.
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