ILMNHIGH SIGNALFINANCIAL10-K

Illumina executed a dramatic operational turnaround, swinging from an $833M operating loss to $807M operating income while completing the GRAIL divestiture and acquiring SomaLogic assets.

This represents a fundamental transformation of Illumina's business following regulatory pressure to divest GRAIL, with the company successfully returning to profitability while pivoting toward proteomics through the SomaLogic acquisition. However, the market value decline from $14.7B to $9.2B indicates investor skepticism about the company's post-divestiture prospects and new strategic direction.

Comparing 2026-02-12 vs 2025-02-12View on EDGAR →
FINANCIAL ANALYSIS

Illumina delivered exceptional financial recovery with operating income improving by nearly $1.7 billion year-over-year and net income swinging from a $1.2B loss to $850M profit, while operating cash flow grew 29% to $1.1B. The company significantly increased share buybacks to $742M, demonstrating confidence in its turnaround, though interest expense nearly tripled to $77M suggesting higher debt levels. Current assets grew 20% and stockholders' equity increased 15%, indicating a strengthened balance sheet position following the strategic restructuring, though R&D spending declined 17% which may signal reduced investment in innovation during the transition period.

FINANCIAL STATEMENT CHANGES
Share Buybacks
Cash Flow
+539.7%
$116.0M$742.0M

Share repurchases increased 539.7% — management returning capital, signals confidence in intrinsic value.

Operating Income
P&L
+196.9%
-$833.0M$807.0M

Operating leverage kicking in — revenue growth outpacing cost growth, a hallmark of scaling businesses.

Interest Expense
P&L
+196.2%
$26.0M$77.0M

Interest expense surged 196.2% — significant debt increase or rising rates materially impacting earnings.

Net Income
P&L
+169.5%
-$1.2B$850.0M

Net income grew 169.5% — bottom-line growth signals improving overall business health.

Operating Cash Flow
Cash Flow
+28.9%
$837.0M$1.1B

Operating cash flow grew 28.9% — strong conversion of earnings to cash, healthy business fundamentals.

Current Assets
Balance Sheet
+19.8%
$2.7B$3.3B

Current assets grew 19.8% — improving short-term liquidity or inventory/receivables build.

R&D Expense
P&L
-17.3%
$1.2B$967.0M

R&D spending cut 17.3% — could signal cost discipline or concerning reduction in innovation investment.

Accounts Receivable
Balance Sheet
+16.2%
$735.0M$854.0M

Receivables grew 16.2% — monitor days sales outstanding for collection efficiency.

Stockholders Equity
Balance Sheet
+14.7%
$2.4B$2.7B

Equity base grew 14.7% — retained earnings accumulation or equity issuance strengthening the balance sheet.

LANGUAGE CHANGES
NEW — 2026-02-12
PRIOR — 2025-02-12
ADDED
The aggregate market value of the common stock held by non-affiliates of the registrant as of June 29, 2025 (the last business day of the registrant s most recently completed second quarter), based on the closing price for the common stock on The Nasdaq Global Select Market on June 27, 2025 (the last trading day before June 29, 2025), was $ 9.2 billion.
(SomaLogic) and certain other assets from Standard BioTools Inc.
(Standard BioTools), including the future conduct and growth of the SomaLogic business and the proteomics market and our ability to successfully integrate SomaLogic into our existing operations and SomaLogic s technology and products into our portfolio; our estimate of the cost impact on Illumina of the tariffs announced by the U.S.
Government and other countries beginning in April 2025; and other expectations, beliefs, plans, strategies, anticipated developments, and other matters that are not historical facts.
government administration; risks and uncertainties regarding legal and regulatory proceedings; uncertainty regarding the impact of tariffs imposed by the U.S.
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REMOVED
The aggregate market value of the common stock held by non-affiliates of the registrant as of June 30, 2024 (the last business day of the registrant s most recently completed second quarter), based on the closing price for the common stock on The Nasdaq Global Select Market on June 28, 2024 (the last trading day before June 30, 2024), was $ 14.7 billion.
(f/k/a GRAIL, LLC) (GRAIL); and other expectations, beliefs, plans, strategies, anticipated developments, and other matters that are not historical facts.
government administration; risks and uncertainties regarding legal and regulatory proceedings; 2 the impact of tariffs recently imposed by the U.S.
References to 2024, 2023, and 2022 refer to fiscal years ended December 29, 2024, December 31, 2023, and January 1, 2023, respectively, which were all 52 weeks.
Variations among organisms are due, in large part, to differences in their DNA sequences.
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