HUMAHIGH SIGNALOPERATIONAL10-K

HUMA achieved FDA approval and commercial launch of Symvess for vascular trauma, marking a critical transition from clinical-stage to revenue-generating company.

The company successfully launched its first commercial product and dramatically improved its financial position, with stockholders' equity swinging from -$52.7M to +$3.1M and net losses narrowing by 72.5%. The removal of language about filing a BLA and addition of commercial launch details indicates FDA approval was granted, representing a major operational milestone that validates the company's technology platform.

Comparing 2026-03-27 vs 2025-03-31View on EDGAR →
FINANCIAL ANALYSIS

HUMA's financials show a remarkable turnaround with stockholders' equity improving by over $55M to become positive, while net losses decreased 72.5% from $148.7M to $40.8M despite the company being in commercial launch mode. Current assets grew 41.7% and total liabilities decreased 40.6%, indicating stronger liquidity and reduced financial obligations. The combination of improved cash position (+12.4%) with substantially lower R&D spending (-21.8%) and reduced capital expenditures suggests the company has successfully transitioned from heavy development investment to a more sustainable commercial operating model.

FINANCIAL STATEMENT CHANGES
Stockholders Equity
Balance Sheet
+105.9%
-$52.7M$3.1M

Equity base grew 105.9% — retained earnings accumulation or equity issuance strengthening the balance sheet.

Net Income
P&L
+72.5%
-$148.7M-$40.8M

Net income grew 72.5% — bottom-line growth signals improving overall business health.

Capital Expenditure
Cash Flow
-43.8%
$1.6M$884K

Capex reduced 43.8% — investment cycle winding down or capital discipline; may improve near-term free cash flow.

Current Assets
Balance Sheet
+41.7%
$47.9M$67.8M

Current assets grew 41.7% — improving short-term liquidity or inventory/receivables build.

Total Liabilities
Balance Sheet
-40.6%
$190.5M$113.3M

Liabilities reduced 40.6% — deleveraging improves balance sheet strength and financial flexibility.

R&D Expense
P&L
-21.8%
$88.6M$69.3M

R&D spending cut 21.8% — could signal cost discipline or concerning reduction in innovation investment.

Total Assets
Balance Sheet
-15.6%
$137.9M$116.4M

Total assets contracted 15.6% — asset sales, write-downs, or balance sheet optimization underway.

Cash & Equivalents
Balance Sheet
+12.4%
$44.9M$50.5M

Cash grew 12.4% — improving liquidity position supports investment and shareholder returns.

LANGUAGE CHANGES
NEW — 2026-03-27
PRIOR — 2025-03-31
ADDED
As of March 24, 2026, 222,019,108 shares of common stock, par value $0.0001, were issued and outstanding.
We are initially using our proprietary, scientific technology platform to engineer and manufacture acellular tissue engineered vessels, or ATEVs.
As of December 31, 2025, our ATEVs have been implanted in approximately 636 patients in clinical trials as well as additional patients following the U.S.
commercial launch of Symvess in the vascular trauma indication.
In addition to vascular trauma, we are currently conducting a Phase 3 trial of our 6 millimeter ATEV in AV access for hemodialysis, and previously completed Phase 2 trials in PAD.
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REMOVED
As of March 27, 2025, 155,118,816 shares of common stock, par value $0.0001, were issued and outstanding.
We are initially using our proprietary, scientific technology platform to engineer and manufacture acellular tissue engineered vessels, or ATEVs TM .
As of December 31, 2024, our ATEVs have been implanted in approximately 601 patients.
In addition to vascular trauma, we and our collaborators are currently conducting Phase 3 and Phase 2 trials of our 6 millimeter ATEV in AV access for hemodialysis and PAD.
In addition, in 2018 our ATEV product candidate was assigned a priority designation by the Secretary of Defense under Public Law 115-92, enacted to expedite the FDA s review of products that are intended to diagnose, treat or prevent serious or life-threatening conditions facing American military personnel.
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