DMACMEDIUM SIGNALFINANCIAL10-K

DMAC expanded its clinical focus to include fetal growth restriction while operating cash outflows increased meaningfully alongside higher R&D spending.

The company broadened its therapeutic scope from two to three indications (adding FGR to AIS and PE), suggesting expanded market opportunity but also increased development complexity. The substantial increase in share count from 42.9M to 53.9M shares indicates recent equity financing activity, which helped strengthen the balance sheet but diluted existing shareholders.

Comparing 2026-03-30 vs 2025-03-17View on EDGAR →
FINANCIAL ANALYSIS

DMAC's financial position strengthened with total assets growing 32% to $61.4M and stockholders' equity rising 38% to $56.1M, reflecting capital raising activities. However, operating performance deteriorated as R&D expenses increased 29% to $24.6M, contributing to wider net losses and operating cash outflows that grew to $29.1M. The company appears to have successfully raised capital to fund expanded clinical programs but is burning cash at an accelerated rate.

FINANCIAL STATEMENT CHANGES
Capital Expenditure
Cash Flow
+60%
$25K$40K

Capital expenditure jumped 60% — major investment cycle underway; assess returns on deployment.

Stockholders Equity
Balance Sheet
+37.8%
$40.7M$56.1M

Equity base grew 37.8% — retained earnings accumulation or equity issuance strengthening the balance sheet.

Current Assets
Balance Sheet
+35.9%
$44.6M$60.6M

Current assets grew 35.9% — improving short-term liquidity or inventory/receivables build.

Net Income
P&L
-34%
-$24.4M-$32.8M

Net income declined 34% — review whether driven by operations, interest costs, or non-recurring items.

Total Assets
Balance Sheet
+32.4%
$46.3M$61.4M

Asset base grew 32.4% — expansion through organic growth, acquisitions, or capital deployment.

Operating Cash Flow
Cash Flow
-31.6%
-$22.1M-$29.1M

Operating cash flow fell 31.6% — earnings quality concerns; investigate working capital changes and non-cash items.

R&D Expense
P&L
+29.2%
$19.1M$24.6M

R&D investment increased 29.2% — signals commitment to future product development, though near-term margin impact.

Operating Income
P&L
-28.9%
-$26.7M-$34.4M

Operating profitability softening — costs rising faster than revenue, watch for margin recovery plan.

LANGUAGE CHANGES
NEW — 2026-03-30
PRIOR — 2025-03-17
ADDED
As of March 27, 2026, there were 53,882,506 voting common shares outstanding.
Securities and Exchange Commission within 120 days after the end of the fiscal year to which this report relates.
Moreover, we operate in a highly competitive and rapidly-changing environment.
Business Overview We are a clinical-stage biopharmaceutical company committed to improving the lives of people suffering from severe ischemic disease with two main clinical programs focused on preeclampsia (PE) / fetal growth restriction (FGR) and acute ischemic stroke (AIS).
We plan to advance DM199 through required clinical trials to create shareholder value by establishing its clinical and commercial potential as a therapy for PE, FGR and AIS.
KLK1 is a serine protease enzyme that plays an important role in the regulation of diverse physiological processes via a molecular mechanism believed to enhance endothelial health, microcirculatory blood flow and tissue perfusion by increasing production of nitric oxide (NO), prostacyclin (PGI 2 ) and endothelium-derived hyperpolarizing factor (EDHF).
In PE and FGR, DM199 is intended to lower blood pressure, enhance endothelial health and improve perfusion to maternal organs and the placenta, potentially disease modifying results that improve both maternal and perinatal outcomes.
Our clinical development program in PE currently centers around an investigator-sponsored safety, tolerability and pharmacodynamic, proof-of-concept Phase 2 study in PE patients being conducted at the Tygerberg Hospital in Cape Town, South Africa.
This Phase 2 study consists of three studies in PE (Part 1a, dose-escalation; Part 1b, dose-expansion; and Part 2, expectant management) and a fourth study in fetal growth restriction (FGR, Part 3, expectant management).
Part 1a topline study results are intended to identify a suitable dose for Parts 1b, 2, and 3.
REMOVED
As of March 14, 2025, there were 42,855,660 voting common shares outstanding.
Moreover, we operate in a very competitive and rapidly-changing environment.
Business Overview We are a clinical stage biopharmaceutical company committed to improving the lives of people suffering from severe ischemic disease with two main clinical programs focused on acute ischemic stroke (AIS) and preeclampsia (PE).
We plan to advance DM199 through required clinical trials to create shareholder value by establishing its clinical and commercial potential as a therapy for AIS and PE.
Our lead candidate DM199 is a recombinant form of human tissue kallikrein-1 , which is a synthetic version of the naturally occurring protease enzyme kallikrein-1 and the first and only rhKLK1 undergoing global clinical development studies in both AIS and PE.
Naturally occurring KLK1 (extracted from human urine or porcine pancreas) has been an approved therapeutic agent in Asia for decades in the treatment of AIS and hypertension associated with cardiorenal disease.
DM199 is produced using recombinant DNA technology without the need for extracted human or animal tissue sources and thereby eliminates risk of pathogen transmission.
KLK1 is a serine protease enzyme that plays an important role in the regulation of diverse physiological processes via a molecular mechanism that may enhance microcirculatory blood flow and tissue perfusion by increasing production of nitric oxide (NO), prostacyclin (PGI2) and endothelium-derived hyperpolarizing factor (EDHF).
In preeclampsia, DM199 is intended to lower blood pressure, enhance endothelial health and improve perfusion to maternal organs and the placenta, potentially disease modifying outcomes improving both maternal and perinatal outcomes.
We are developing DM199 to address two major critical unmet needs.
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