CTNMHIGH SIGNALFINANCIAL10-K

CTNM's operating cash burn increased substantially while the company advanced its drug development portfolio, though a strong balance sheet provides adequate runway.

The meaningful deterioration in operating cash flow combined with higher R&D spending signals the company is in an intensive development phase for its pipeline candidates PIPE-791 and PIPE-307. While losses widened across multiple metrics, the substantial increase in stockholders' equity suggests recent capital raising activities have strengthened the financial position to fund operations.

Comparing 2026-03-05 vs 2025-03-06View on EDGAR →
FINANCIAL ANALYSIS

CTNM's financial profile reflects a clinical-stage biotech ramping development activities, with operating cash burn increasing substantially and R&D expenses growing meaningfully by 34%. Net losses widened to $60.0M as operating losses deepened, but total assets grew 30% to $276.6M with stockholders' equity rising 32% to $261.0M, indicating successful capital raising that provides funding runway for the expanded development programs.

FINANCIAL STATEMENT CHANGES
Operating Cash Flow
Cash Flow
-68.4%
-$32.8M-$55.3M

Operating cash flow fell 68.4% — earnings quality concerns; investigate working capital changes and non-cash items.

Capital Expenditure
Cash Flow
-55.1%
$514K$231K

Capex reduced 55.1% — investment cycle winding down or capital discipline; may improve near-term free cash flow.

Net Income
P&L
-41.9%
-$42.3M-$60.0M

Net income declined 41.9% — review whether driven by operations, interest costs, or non-recurring items.

R&D Expense
P&L
+34.1%
$38.4M$51.5M

R&D investment increased 34.1% — signals commitment to future product development, though near-term margin impact.

Operating Income
P&L
-33.7%
-$50.9M-$68.1M

Operating income deteriorated sharply — investigate whether driven by one-time charges or structural cost issues.

Stockholders Equity
Balance Sheet
+31.8%
$198.1M$261.0M

Equity base grew 31.8% — retained earnings accumulation or equity issuance strengthening the balance sheet.

Total Assets
Balance Sheet
+30%
$212.8M$276.6M

Asset base grew 30% — expansion through organic growth, acquisitions, or capital deployment.

Current Assets
Balance Sheet
+29.8%
$206.4M$267.9M

Current assets grew 29.8% — improving short-term liquidity or inventory/receivables build.

LANGUAGE CHANGES
NEW — 2026-03-05
PRIOR — 2025-03-06
ADDED
As of February 27, 2026, the registrant had 37,336,036 total shares outstanding, of which there were 32,673,536 shares of Class A common stock, $0.001 par value per share, outstanding and 4,662,500 shares of Class B common stock, $0.001 par value per share, outstanding.
You should not rely upon forward-looking statements as predictions of future events.
We undertake no obligation to update publicly any forward-looking statements for any reason after the date of this report to conform these statements to actual results or to changes in our expectations, except as required by law.
We focus on developing selective compounds targeting challenging molecular pathways and have built a portfolio of small molecule drug candidates.
LPA1R antagonism is a clinically validated mechanism in IPF, and we believe that our preclinical studies, Phase 1 healthy volunteer data, and Phase 1 positron emission tomography ( PET ) data support the development of PIPE-791 for IPF and chronic pain.
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REMOVED
false --12-31 FY 2024 true true true false true true 0.001 0.001 0 0 0 16,940,594 15,906,236 15,906,236 0.001 0.001 200,000,000 39,630,511 19,125,377 19,125,377 2,349,554 2,349,554 0.001 0.001 20,000,000 6,729,172 6,729,172 0 0 0 0.001 0.001 10,000,000 0 0 0 0 0 110 10,912 2 5 0 10 6.03 6.08 5 5 3 1 false false false false Other segment items primarily include change in fair value of warrant liability, change in fair value of investor rights and obligations liability, and other expense, net.
Basic and diluted per share amounts are the same for Class A and Class B shares.
As of February 28, 2025, the registrant had 25,871,549 total shares outstanding, of which there were 19,142,377 shares of Class A common stock, $0.001 par value per share, outstanding and 6,729,172 shares of Class B common stock, $0.001 par value per share, outstanding.
We undertake no obligation to update publicly any forward-looking statements for any reason after the date of this report to conform these statements to actual results or to changes in our expectations.
SUMMARY OF RISKS ASSOCIATED WITH OUR BUSINESS We face risks and uncertainties associated with our business, many of which are beyond our control.
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