CLRBHIGH SIGNALFINANCIAL10-K

CLRB's outstanding shares collapsed 91% from 46.1M to 4.2M shares while the company achieved significant regulatory milestones including FDA Breakthrough Therapy Designation for iopofosine.

The dramatic reduction in share count from 46.1M to 4.2M shares suggests a major corporate restructuring event such as a reverse stock split, which typically indicates severe financial distress or stock price issues. However, the company simultaneously achieved important regulatory progress with FDA Breakthrough Therapy Designation and positive EMA guidance for iopofosine, creating a complex risk-opportunity dynamic for investors.

Comparing 2026-03-04 vs 2025-03-13View on EDGAR →
FINANCIAL ANALYSIS

The financial statements show a company in significant cost-cutting mode with R&D expenses declining 56% to $11.5M and operating losses improving 56% to -$23.0M, indicating either reduced clinical trial activity or successful expense management. Cash position declined 43% to $13.2M while total liabilities fell 48% to $5.1M, suggesting the company is burning cash but also paying down obligations. The overall picture shows a biotech company managing through a cash crunch while making meaningful progress on its lead drug candidate.

FINANCIAL STATEMENT CHANGES
Capital Expenditure
Cash Flow
-94.4%
$104K$6K

Capex reduced 94.4% — investment cycle winding down or capital discipline; may improve near-term free cash flow.

R&D Expense
P&L
-56%
$26.1M$11.5M

R&D spending cut 56% — could signal cost discipline or concerning reduction in innovation investment.

Operating Income
P&L
+55.6%
-$51.8M-$23.0M

Operating leverage kicking in — revenue growth outpacing cost growth, a hallmark of scaling businesses.

Operating Cash Flow
Cash Flow
+51.4%
-$47.6M-$23.1M

Operating cash flow surged 51.4% — exceptional cash generation, highest quality earnings signal.

Net Income
P&L
+51.1%
-$44.6M-$21.8M

Net income grew 51.1% — bottom-line growth signals improving overall business health.

Current Liabilities
Balance Sheet
-49.4%
$9.4M$4.7M

Current liabilities reduced — improved short-term financial position and working capital health.

Total Liabilities
Balance Sheet
-48.4%
$9.8M$5.1M

Liabilities reduced 48.4% — deleveraging improves balance sheet strength and financial flexibility.

Cash & Equivalents
Balance Sheet
-43.3%
$23.3M$13.2M

Cash declined 43.3% — significant cash burn or deployment; verify adequacy of remaining liquidity runway.

Current Assets
Balance Sheet
-42.1%
$24.3M$14.0M

Current assets declined 42.1% — monitor working capital adequacy and short-term liquidity.

Total Assets
Balance Sheet
-41.2%
$25.5M$15.0M

Total assets contracted 41.2% — asset sales, write-downs, or balance sheet optimization underway.

LANGUAGE CHANGES
NEW — 2026-03-04
PRIOR — 2025-03-13
ADDED
As of February 24, 2026, there were 4,240,129 shares of the registrant s $0.00001 par value common stock outstanding.
Our three lead programs are: CLR 121125 (CLR 125), an iodine-125 Auger-emitting program, prepared to enter a clinical trial in 2025; CLR 121225 (CLR 225), an actinium-225 based program; and iopofosine I 131 (iopofosine I 131, or simply iopofosine), a beta-emitting iodine-131 based program which has been studied extensively, as described below.
On June 4, 2025, the Company announced that the U.S Food and Drug Administration (the FDA ) granted Breakthrough Therapy Designation for iopofosine I 131, as a radioconjugate monotherapy for the treatment of relapsed/refractory Waldenstrom macroglobulinemia (r/r WM).
On October 6, 2025, the Company announced that after a scientific advice procedure, the Scientific Advice Working Party (SAWP) of the European Medicines Agency (EMA) advised that filing for a Conditional Marketing Authorization (CMA) for iopofosine I 131 as a treatment for post - Bruton Tyrosine Kinase inhibitor (BTKi) refractory patients with Waldenstrom macroglobulinemia (WM) could be acceptable for a CMA.
CLR 125, an Auger-emitting PRC, utilizes iodine-125 as its radiation source and has been observed to show tolerability with minimal toxicities in animal models.
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REMOVED
As of March 7, 2025, there were 46,079,875 shares of the registrant s $0.00001 par value common stock outstanding.
Our three lead programs are: iopofosine I 131 (iopofosine), a beta-emitting iodine-131 based program which has been studied extensively, as described below; CLR 121225, an actinium-225 based program; and CLR 121125, an iodine-125 Auger-emitting program, both prepared to enter clinical trials in 2025.
Iopofosine, the beta-emitting PRC, utilizes iodine-131 and was studied in our CLOVER-WaM Phase 2 study of iopofosine in patients with relapsed/refractory (r/r) Waldenstrom s macroglobulinemia (WM), and our Phase 2b studies in r/r multiple myeloma (MM) patients and r/r central nervous system lymphoma (CNSL) are ongoing.
As with all clinical trials, adverse events, serious adverse events or fatalities may arise during a clinical trial resulting from medical problems that may not be related to clinical trial treatments.
Furthermore, due to recent communications with the FDA regarding a confirmatory study to support accelerated approval and the regulatory submission for iopofosine, the Company is, in addition to determining the availability of funding for such a study, pursuing strategic options for the further development and commercialization of this product candidate.
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