ASMBMEDIUM SIGNALFINANCIAL10-K

Assembly Biosciences showed meaningful improvements in operating performance with substantially reduced losses and interest expense while maintaining R&D investment levels.

The company demonstrated notable progress in controlling costs and reducing financial losses, though it remains pre-profitability as a biotech company. The significant reduction in total liabilities combined with improved cash position suggests better financial positioning, while the removal of specific clinical timeline guidance may indicate more cautious forward-looking planning.

Comparing 2026-03-19 vs 2025-03-20View on EDGAR →
FINANCIAL ANALYSIS

Assembly Biosciences showed substantially improved financial performance with operating losses and net losses both meaningfully reduced year-over-year, while R&D expenses grew modestly by 16%. The balance sheet strengthened considerably with cash increasing 52% to $58.5M and total liabilities declining 41%, while interest expense dropped dramatically from $2.0M to $117K. Operating cash flow improved modestly, reflecting the company's progress in managing its cash burn rate while continuing to invest in research and development activities.

FINANCIAL STATEMENT CHANGES
Interest Expense
P&L
-94.3%
$2.0M$117K

Interest expense declined — debt repayment or refinancing at lower rates improving earnings quality.

Net Income
P&L
+84.8%
-$40.2M-$6.1M

Net income grew 84.8% — bottom-line growth signals improving overall business health.

Operating Income
P&L
+73.3%
-$45.4M-$12.1M

Operating leverage kicking in — revenue growth outpacing cost growth, a hallmark of scaling businesses.

Cash & Equivalents
Balance Sheet
+52.4%
$38.3M$58.5M

Cash position surged 52.4% — strong cash generation or capital raise providing significant financial cushion.

Total Liabilities
Balance Sheet
-40.8%
$85.8M$50.8M

Liabilities reduced 40.8% — deleveraging improves balance sheet strength and financial flexibility.

Operating Cash Flow
Cash Flow
+19.6%
-$51.1M-$41.1M

Operating cash flow grew 19.6% — strong conversion of earnings to cash, healthy business fundamentals.

R&D Expense
P&L
+15.9%
$55.9M$64.8M

R&D investment increased 15.9% — signals commitment to future product development, though near-term margin impact.

LANGUAGE CHANGES
NEW — 2026-03-19
PRIOR — 2025-03-20
ADDED
As of March 13, 2026, there were 15,862,705 shares of the registrant s common stock, $0.001 par value per share, outstanding.
Form 10-K Summary 66 Financial Statements F- 1 1 References to Assembly Biosciences, Inc.
Forward-Looki ng Statements This Annual Report on Form 10-K contains forward-looking statements that are subject to certain risks and uncertainties, including, without limitation, those set forth in Part I, Item 1A under the heading Risk Factors, that could cause actual results to materially differ.
Such risks and uncertainties include, among other things: our ability to realize the potential benefits of our collaboration with Gilead Sciences, Inc.
In particular, forward-looking statements include, but are not limited to, statements regarding the timing of commencement of future clinical studies involving our therapeutic product candidates or therapeutic product candidates that Gilead has licensed from us; and our ability to successfully complete, and receive favorable results in, clinical studies for our product candidates.
+7 more — sign up free →
REMOVED
As of March 14, 2025, there were 7,503,385 shares of the registrant s common stock, $0.001 par value per share, outstanding.
Form 10-K Summary 53 Financial Statements F- 1 i References to Assembly Biosciences, Inc.
Such risks and uncertainties include, among other things: our ability to maintain financial resources necessary to continue our research activities, clinical studies and other business operations; our ability to realize the potential benefits of our collaboration with Gilead Sciences, Inc.
administration in 2025; and results of nonclinical studies may not be representative of disease behavior in a clinical setting and may not be predictive of the outcomes of clinical studies.
In particular, forward-looking statements include, but are not limited to, statements regarding the timing of commencement of future clinical studies involving our therapeutic product candidates; and our ability to successfully complete, and receive favorable results in, clinical studies for our product candidates.
+7 more — sign up free →
MORE FINANCIAL SIGNALS
CRMHIGHSalesforce significantly increased debt by 71% to $14.4B while simultaneously ac...
2026-03-02
UNHHIGHUNH's operating income plummeted 41% despite 12% revenue growth, indicating seve...
2026-03-02
PFEHIGHPfizer achieved a dramatic 87.3% reduction in total debt from $31.4B to $4.0B, r...
2026-02-26
GILDHIGHGILD dramatically increased R&D spending by 81.5% to $9.1B while introducing new...
2026-02-24
ANALYZE ANY FILING FREE

See what changed in your portfolio's filings

500+ US-listed companies analyzed. Language delta, financial analysis, instant signal scoring.

Try Tracenotes free →