APREHIGH SIGNALFINANCIAL10-K

APRE shows significant financial deterioration with a 108% increase in outstanding shares alongside substantial declines in cash, assets, and R&D spending, indicating potential dilutive financing and operational scaling back.

The doubling of outstanding shares from 5.5M to 11.5M suggests major dilutive equity financing, which typically pressures existing shareholder value. Combined with the 36% cash burn and 37% reduction in R&D spending, this indicates the company may be conserving resources and potentially scaling back drug development activities during a challenging financial period.

Comparing 2026-03-16 vs 2025-03-25View on EDGAR →
FINANCIAL ANALYSIS

APRE's financial position weakened considerably, with cash declining 36% to $14.6M, total assets shrinking 34%, and stockholders' equity falling 36% to $12.4M. The company substantially reduced R&D spending by 37% to $23.9M and cut capital expenditures by 83%, while total liabilities decreased 56%. This pattern suggests aggressive cost-cutting measures and cash conservation efforts, likely necessitated by the significant share dilution and declining cash position.

FINANCIAL STATEMENT CHANGES
Capital Expenditure
Cash Flow
-83.4%
$93K$15K

Capex reduced 83.4% — investment cycle winding down or capital discipline; may improve near-term free cash flow.

Total Liabilities
Balance Sheet
-56.2%
$7.3M$3.2M

Liabilities reduced 56.2% — deleveraging improves balance sheet strength and financial flexibility.

R&D Expense
P&L
-36.9%
$37.9M$23.9M

R&D spending cut 36.9% — could signal cost discipline or concerning reduction in innovation investment.

Cash & Equivalents
Balance Sheet
-36.1%
$22.8M$14.6M

Cash declined 36.1% — significant cash burn or deployment; verify adequacy of remaining liquidity runway.

Stockholders Equity
Balance Sheet
-35.6%
$19.3M$12.4M

Equity declined sharply — large losses, buybacks, or write-downs reducing book value significantly.

Current Assets
Balance Sheet
-34%
$23.6M$15.6M

Current assets declined 34% — monitor working capital adequacy and short-term liquidity.

Total Assets
Balance Sheet
-33.6%
$24.0M$15.9M

Total assets contracted 33.6% — asset sales, write-downs, or balance sheet optimization underway.

Current Liabilities
Balance Sheet
-17.8%
$3.4M$2.8M

Current liabilities reduced — improved short-term financial position and working capital health.

LANGUAGE CHANGES
NEW — 2026-03-16
PRIOR — 2025-03-25
ADDED
There were 11,452,452 shares of the registrant s common stock, $0.001 par value, outstanding as of March 16, 2026.
This Form 10-K may include trademarks, tradenames, and service marks that are the property of other organizations.
Business Overview We are a clinical-stage precision medicine oncology company focused on the discovery and development of targeted therapies for patients with biomarker-defined cancers.
Our approach focuses on matching treatments to specific cancer-related genetic mutations to potentially maximize effectiveness and minimize side effects.
Specifically, we develop small molecule inhibitors designed to exploit genetic mutations in cancer to widen the therapeutic window and intended to make treatments more effective at destroying cancer cells while sparing healthy tissue.
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REMOVED
There were 5,491,953 shares of the registrant s common stock, $0.001 par value, outstanding as of March 25, 2025.
Business Overview We are a clinical-stage biopharmaceutical company focused on precision oncology through synthetic lethality.
Our approach is built upon a platform of integrated discovery technologies to enrich our pipeline with novel targets in synthetic lethality and cancer treatment.
Together with our expertise in small molecule drug discovery, we are applying the capabilities of our discovery platform to the development of new precision oncology therapies and the identification of patient populations most likely to benefit.
Following our acquisition of Atrin, we shifted the focus of our activities to the assets acquired from Atrin.
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