ALXOHIGH SIGNALFINANCIAL10-K

ALXO experienced severe financial deterioration with stockholders' equity collapsing 77% to $26M and current assets falling 62%, while expanding its business description beyond CD47-focused immuno-oncology to include a second ADC product candidate.

The dramatic decline in equity and assets signals potential liquidity stress and dilution from equity raises or asset sales. While operating losses improved 27%, the company's financial cushion has been severely eroded, creating near-term funding pressure for continued operations.

Comparing 2026-03-09 vs 2025-03-06View on EDGAR →
FINANCIAL ANALYSIS

ALXO's balance sheet deteriorated dramatically with stockholders' equity plunging 77% to $26M and total assets falling 60% to $59M, while current liabilities increased 33% to $24.6M. Operating performance showed mixed signals as R&D expenses declined 34% and operating losses improved 27%, but this appears driven by cost-cutting rather than operational progress. The massive asset decline combined with rising liabilities and reduced capital expenditures suggests the company is burning through cash reserves and may face funding challenges to sustain operations.

FINANCIAL STATEMENT CHANGES
Stockholders Equity
Balance Sheet
-77.1%
$113.6M$26.0M

Equity declined sharply — large losses, buybacks, or write-downs reducing book value significantly.

Current Assets
Balance Sheet
-62.2%
$134.4M$50.7M

Current assets declined 62.2% — monitor working capital adequacy and short-term liquidity.

Total Assets
Balance Sheet
-60%
$147.8M$59.0M

Total assets contracted 60% — asset sales, write-downs, or balance sheet optimization underway.

Capital Expenditure
Cash Flow
-52.6%
$447K$212K

Capex reduced 52.6% — investment cycle winding down or capital discipline; may improve near-term free cash flow.

R&D Expense
P&L
-33.8%
$116.4M$77.0M

R&D spending cut 33.8% — could signal cost discipline or concerning reduction in innovation investment.

Current Liabilities
Balance Sheet
+32.7%
$18.5M$24.6M

Current liabilities surged 32.7% — significant near-term obligations; verify ability to meet short-term debt.

Operating Cash Flow
Cash Flow
+31%
-$121.9M-$84.1M

Operating cash flow surged 31% — exceptional cash generation, highest quality earnings signal.

Operating Income
P&L
+27%
-$142.5M-$104.0M

Operating income improving — cost discipline or growing revenue base absorbing fixed costs.

Net Income
P&L
+24.6%
-$134.8M-$101.7M

Net income grew 24.6% — bottom-line growth signals improving overall business health.

LANGUAGE CHANGES
NEW — 2026-03-09
PRIOR — 2025-03-06
ADDED
federal government shutdowns, economic downturns, bank failures or instability in the financial services sector, or geopolitical risks, disasters, and medical or public health crises, such as the COVID-19 pandemic; our plans for and prospects of our acquisitions and other business development activities, and our ability to successfully capitalize on these opportunities; changes in our financial and internal controls; and our anticipated use of our existing cash and cash equivalents, short-term and long-term investments, and the funds available from our term loan.
BUSINESS Overview We are a clinical-stage biotechnology company advancing a pipeline of novel therapies designed to treat cancer and extend patients lives.
Our clinical pipeline includes two clinical-stage product candidates, the CD47 blocker evorpacept and an epidermal growth factor receptor (EGFR)-targeted antibody drug candidate (ADC) ALX2004.
Our lead product candidate, evorpacept, has demonstrated potential to serve as a cornerstone therapy upon which the future of immuno-oncology can be built for patients whose cancer over-expresses CD47.
Evorpacept is currently being evaluated in combination with trastuzumab and chemotherapy in patients with metastatic HER2-positive breast cancer in the Phase 2 ASPEN-09-Breast clinical trial and is also being studied in clinical trials with other targeted anti-cancer antibodies.
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REMOVED
BUSINESS Overview We are a clinical-stage immuno-oncology company focused on helping patients fight cancer by developing therapies that block the CD47 immune checkpoint and bridge the innate and adaptive immune system.
Our lead product candidate, the CD47 blocker evorpacept, is currently in multiple Phase 1 and 2 clinical trials.
Cancer cells leverage CD47, a cell surface protein, as a don t eat me signal to evade macrophage phagocytosis or as a don t activate T-cells signal that prevents activation of T-cells by dendritic cells.
The CD47 binding domain of evorpacept is an affinity enhanced extracellular domain of SIRP , a protein that is the natural receptor to CD47 found on myeloid cells.
We believe evorpacept has a favorable tolerability profile that may enable higher dosing levels and greater combination potential with other leading anti-cancer agents.
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