ALDXMEDIUM SIGNALOPERATIONAL10-K

ALDX shifted strategic focus from metabolic diseases to concentrate solely on immune-mediated diseases while significantly reducing R&D spending by 47%.

The company has narrowed its therapeutic focus and added primary vitreoretinal lymphoma as a new indication for ADX-2191, suggesting a more targeted strategic approach. However, the substantial reduction in R&D expenses raises questions about the scope and pace of future drug development activities, which is critical for a biotechnology company's growth prospects.

Comparing 2026-02-27 vs 2025-02-28View on EDGAR →
FINANCIAL ANALYSIS

The financial picture shows a mixed but concerning trend - while operational losses improved significantly (operating loss decreased 41% and net loss decreased 39%), this improvement came alongside a dramatic 47% cut in R&D spending, which is the lifeblood of biotech operations. The balance sheet deteriorated substantially with total assets declining 31% and stockholders' equity falling 38%, though cash position improved 29%, likely from financing activities. Current liabilities spiked 50%, indicating increased near-term obligations, while the improved cash flow from operations (-$33M vs -$43M) reflects the reduced R&D expenditures rather than revenue growth.

FINANCIAL STATEMENT CHANGES
Current Liabilities
Balance Sheet
+49.5%
$18.6M$27.8M

Current liabilities surged 49.5% — significant near-term obligations; verify ability to meet short-term debt.

R&D Expense
P&L
-46.8%
$48.2M$25.7M

R&D spending cut 46.8% — could signal cost discipline or concerning reduction in innovation investment.

Operating Income
P&L
+41.3%
-$60.1M-$35.3M

Operating leverage kicking in — revenue growth outpacing cost growth, a hallmark of scaling businesses.

Net Income
P&L
+39.4%
-$55.9M-$33.8M

Net income grew 39.4% — bottom-line growth signals improving overall business health.

Stockholders Equity
Balance Sheet
-37.7%
$71.0M$44.3M

Equity declined sharply — large losses, buybacks, or write-downs reducing book value significantly.

Total Assets
Balance Sheet
-31.1%
$104.6M$72.1M

Total assets contracted 31.1% — asset sales, write-downs, or balance sheet optimization underway.

Current Assets
Balance Sheet
-31%
$104.1M$71.8M

Current assets declined 31% — monitor working capital adequacy and short-term liquidity.

Cash & Equivalents
Balance Sheet
+28.5%
$54.5M$70.0M

Cash grew 28.5% — improving liquidity position supports investment and shareholder returns.

Operating Cash Flow
Cash Flow
+22.8%
-$43.2M-$33.3M

Operating cash flow grew 22.8% — strong conversion of earnings to cash, healthy business fundamentals.

Interest Expense
P&L
+22.3%
$1.7M$2.1M

Interest costs rose 22.3% — monitor debt levels and coverage ratio in rising rate environment.

LANGUAGE CHANGES
NEW — 2026-02-27
PRIOR — 2025-02-28
ADDED
As of February 27, 2026 there were 60,182,782 share s of the registrant s Common Stock issued and outstanding.
Given associated risk and uncertainties, you should not place undue reliance on these forward-looking statements.
We encourage you to read Management s Discussion and Analysis of Financial Condition and Results of Operations and Risk Factors, as well as our audited consolidated financial statements contained in this annual report on Form 10 K.
B USINESS Overview Aldeyra Therapeutics is a biotechnology company devoted to discovering innovative therapies designed to treat immune-mediated diseases.
Our product candidates include RASP (reactive aldehyde species) modulators ADX-248, ADX-246, and chemically related molecules for the potential treatment of systemic and retinal immune-mediated diseases.
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REMOVED
As of February 26, 2025 there were 59,708,654 shares of the registrant s Common Stock issued and outstanding.
These statements are subject to risks and uncertainties and are based on information currently available to our management.
Given these uncertainties, you should not place undue reliance on these forward-looking statements.
We encourage you to read the discussion and analysis of our financial condition and our financial statements contained in this annual report on Form 10-K.
B USINESS Overview We are a biotechnology company devoted to discovering and developing innovative therapies designed to treat immune-mediated and metabolic diseases.
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