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SYRE Insider Trading & Form 4 Activity

Spyre Therapeutics, Inc.
Last filing: Oct 2, 2026·21 days ago
NEUTRAL · LAST 90 DAYS
0%
buyers
$0
0 buys
$0
0 sells
$0
net buying
0
insiders
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Net flow — last 12 months

Monthly net of insider buys minus sells. Green months indicate net buying; red months indicate net selling.

Most active insiders

Ranked by total transaction value over the last 90 days.

INSIDERBOUGHTSOLDNET
Burrows Scott L
Chief Financial Officer
—
$5.3M
-$5.3M
King-Jones Heidy
See Remarks
—
$5.1M
-$5.1M
Turtle Cameron
Chief Executive Officer
—
$4.1M
-$4.1M
Albers Jeffrey W.
Insider
—
$2.4M
-$2.4M

Recent transactions

Every Form 4 transaction for SYRE, newest first.

SELL10b5-1
Burrows Scott L · Chief Financial Officer
Tx Oct 1·Filed Oct 2·EDGAR ↗
229 sh @ $93.57
$21K
SELL10b5-1
Burrows Scott L · Chief Financial Officer
Tx Oct 1·Filed Oct 2·EDGAR ↗
3,071 sh @ $92.95
$285K
SELL10b5-1
Burrows Scott L · Chief Financial Officer
Tx Oct 1·Filed Oct 2·EDGAR ↗
2,100 sh @ $91.92
$193K
SELL10b5-1
Burrows Scott L · Chief Financial Officer
Tx Oct 1·Filed Oct 2·EDGAR ↗
1,500 sh @ $90.27
$135K
SELL10b5-1
Burrows Scott L · Chief Financial Officer
Tx Oct 1·Filed Oct 2·EDGAR ↗
600 sh @ $89.07
$53K
EXERCISE10b5-1
Burrows Scott L · Chief Financial Officer
Tx Oct 1·Filed Oct 2·EDGAR ↗
7,500 sh @ $14.50
$109K
SELL10b5-1
Turtle Cameron · Chief Executive Officer
Tx Oct 1·Filed Oct 2·EDGAR ↗
100 sh @ $93.91
$9K
SELL10b5-1
Turtle Cameron · Chief Executive Officer
Tx Oct 1·Filed Oct 2·EDGAR ↗
4,990 sh @ $93.37
$466K
SELL10b5-1
King-Jones Heidy · See Remarks
Tx Oct 1·Filed Oct 2·EDGAR ↗
2,600 sh @ $93.46
$243K
SELL10b5-1
King-Jones Heidy · See Remarks
Tx Oct 1·Filed Oct 2·EDGAR ↗
2,100 sh @ $92.70
$195K
SELL10b5-1
King-Jones Heidy · See Remarks
Tx Oct 1·Filed Oct 2·EDGAR ↗
7,228 sh @ $91.35
$660K
SELL10b5-1
King-Jones Heidy · See Remarks
Tx Oct 1·Filed Oct 2·EDGAR ↗
16,605 sh @ $90.35
$1.5M
SELL10b5-1
King-Jones Heidy · See Remarks
Tx Oct 1·Filed Oct 2·EDGAR ↗
400 sh @ $89.24
$36K
EXERCISE10b5-1
King-Jones Heidy · See Remarks
Tx Oct 1·Filed Oct 2·EDGAR ↗
28,933 sh @ $14.50
$420K
SELL10b5-1
Turtle Cameron · Chief Executive Officer
Tx Oct 1·Filed Oct 2·EDGAR ↗
3,989 sh @ $92.31
$368K
SELL10b5-1
Turtle Cameron · Chief Executive Officer
Tx Oct 1·Filed Oct 2·EDGAR ↗
2,638 sh @ $91.49
$241K
SELL10b5-1
Turtle Cameron · Chief Executive Officer
Tx Oct 1·Filed Oct 2·EDGAR ↗
2,683 sh @ $90.10
$242K
SELL10b5-1
Turtle Cameron · Chief Executive Officer
Tx Oct 1·Filed Oct 2·EDGAR ↗
600 sh @ $89.14
$53K
SELL10b5-1
Burrows Scott L · Chief Financial Officer
Tx Sep 30·Filed Oct 2·EDGAR ↗
17,500 sh @ $89.89
$1.6M
EXERCISE10b5-1
Burrows Scott L · Chief Financial Officer
Tx Sep 30·Filed Oct 2·EDGAR ↗
17,500 sh @ $14.50
$254K
SELL10b5-1
King-Jones Heidy · See Remarks
Tx Sep 2·Filed Sep 3·EDGAR ↗
400 sh @ $90.00
$36K
EXERCISE10b5-1
King-Jones Heidy · See Remarks
Tx Sep 2·Filed Sep 3·EDGAR ↗
400 sh @ $14.50
$6K
SELL10b5-1
Burrows Scott L · Chief Financial Officer
Tx Sep 2·Filed Sep 3·EDGAR ↗
18,232 sh @ $89.35
$1.6M
SELL10b5-1
Turtle Cameron · Chief Executive Officer
Tx Sep 1·Filed Sep 3·EDGAR ↗
3,700 sh @ $88.06
$326K
SELL10b5-1
Turtle Cameron · Chief Executive Officer
Tx Sep 1·Filed Sep 3·EDGAR ↗
8,400 sh @ $87.15
$732K
SELL10b5-1
Turtle Cameron · Chief Executive Officer
Tx Sep 1·Filed Sep 3·EDGAR ↗
2,500 sh @ $86.36
$216K
SELL10b5-1
Burrows Scott L · Chief Financial Officer
Tx Sep 1·Filed Sep 3·EDGAR ↗
200 sh @ $89.04
$18K
SELL10b5-1
Burrows Scott L · Chief Financial Officer
Tx Sep 1·Filed Sep 3·EDGAR ↗
2,016 sh @ $88.03
$177K
SELL10b5-1
Burrows Scott L · Chief Financial Officer
Tx Sep 1·Filed Sep 3·EDGAR ↗
4,384 sh @ $87.11
$382K
SELL10b5-1
Burrows Scott L · Chief Financial Officer
Tx Sep 1·Filed Sep 3·EDGAR ↗
900 sh @ $86.25
$78K
EXERCISE10b5-1
Burrows Scott L · Chief Financial Officer
Tx Sep 1·Filed Sep 3·EDGAR ↗
7,500 sh @ $14.50
$109K
SELL10b5-1
King-Jones Heidy · See Remarks
Tx Sep 1·Filed Sep 3·EDGAR ↗
6,206 sh @ $88.17
$547K
SELL10b5-1
King-Jones Heidy · See Remarks
Tx Sep 1·Filed Sep 3·EDGAR ↗
400 sh @ $89.38
$36K
SELL10b5-1
King-Jones Heidy · See Remarks
Tx Sep 1·Filed Sep 3·EDGAR ↗
16,548 sh @ $87.20
$1.4M
SELL10b5-1
King-Jones Heidy · See Remarks
Tx Sep 1·Filed Sep 3·EDGAR ↗
4,845 sh @ $86.40
$419K
EXERCISE10b5-1
King-Jones Heidy · See Remarks
Tx Sep 1·Filed Sep 3·EDGAR ↗
27,999 sh @ $14.50
$406K
SELL10b5-1
Turtle Cameron · Chief Executive Officer
Tx Sep 1·Filed Sep 3·EDGAR ↗
400 sh @ $89.07
$36K
SELL10b5-1
Albers Jeffrey W. · Insider
Tx Aug 7·Filed Aug 10·EDGAR ↗
8,000 sh @ $104.38
$835K
EXERCISE10b5-1
Albers Jeffrey W. · Insider
Tx Aug 7·Filed Aug 10·EDGAR ↗
5,000 sh @ $10.39
$52K
SELL10b5-1
Albers Jeffrey W. · Insider
Tx Aug 7·Filed Aug 10·EDGAR ↗
5,000 sh @ $104.47
$522K
SELL10b5-1
Albers Jeffrey W. · Insider
Tx Aug 7·Filed Aug 10·EDGAR ↗
10,000 sh @ $104.68
$1.0M
EXERCISE10b5-1
Burrows Scott L · Chief Financial Officer
Tx Aug 3·Filed Aug 5·EDGAR ↗
7,500 sh @ $14.50
$109K
SELL10b5-1
Turtle Cameron · Chief Executive Officer
Tx Aug 3·Filed Aug 5·EDGAR ↗
16 sh @ $97.46
$2K
SELL10b5-1
Turtle Cameron · Chief Executive Officer
Tx Aug 3·Filed Aug 5·EDGAR ↗
1,392 sh @ $96.82
$135K
SELL10b5-1
Turtle Cameron · Chief Executive Officer
Tx Aug 3·Filed Aug 5·EDGAR ↗
5,635 sh @ $95.93
$541K
SELL10b5-1
Turtle Cameron · Chief Executive Officer
Tx Aug 3·Filed Aug 5·EDGAR ↗
7,157 sh @ $95.10
$681K
SELL10b5-1
Turtle Cameron · Chief Executive Officer
Tx Aug 3·Filed Aug 5·EDGAR ↗
800 sh @ $93.97
$75K
SELL10b5-1
Burrows Scott L · Chief Financial Officer
Tx Aug 3·Filed Aug 5·EDGAR ↗
100 sh @ $97.10
$10K
SELL10b5-1
Burrows Scott L · Chief Financial Officer
Tx Aug 3·Filed Aug 5·EDGAR ↗
2,300 sh @ $96.30
$221K
SELL10b5-1
Burrows Scott L · Chief Financial Officer
Tx Aug 3·Filed Aug 5·EDGAR ↗
5,100 sh @ $95.21
$486K

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About SYRE insider trading data

Form 4 is the SEC filing required when an officer, director, or 10% owner of a public company buys or sells the company's stock. By law, these filings must be submitted within two business days of the trade. Tracenotes pulls every Form 4 filing for SYRE from EDGAR, parses it, and surfaces the activity on this page.

What insider buying tells you. Open-market purchases by insiders are widely studied as a meaningful signal. Unlike stock awards (which are compensation, not conviction), an executive spending their own money to buy shares of the company they run is a vote of confidence. Studies have found insider-buying clusters — three or more insiders buying within a short window — outperform the broader market over the following year.

What insider selling tells you. Selling is noisier. Many sales are pre-scheduled under SEC Rule 10b5-1 plans, which let insiders sell on a fixed schedule regardless of company news. We label these "10b5-1" so you can see them. Discretionary sales — sales not tied to a plan — are more meaningful, especially when multiple insiders sell in quick succession.

Tracenotes methodology. We scan EDGAR daily for new Form 4 filings, parse them into individual transactions, and detect clusters when three or more distinct insiders buy or sell within a 14-day window. The data on this page covers the last 12 months. For deeper analysis, Tracenotes also runs language-change detection on 10-K and 10-Q filings — that's our core product.

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Frequently asked questions

What is a Form 4 filing?

Form 4 is the SEC disclosure required when a company insider — an officer, director, or 10% owner — buys or sells the company's stock. By law these filings must be submitted within two business days of the trade.

Is insider buying SYRE always bullish?

Open-market purchases by insiders are widely viewed as a bullish signal because executives are spending their own money. Stock awards and option exercises are part of compensation and don't carry the same weight, which is why we treat them separately on this page.

What is a 10b5-1 trade?

A trade made under SEC Rule 10b5-1, which lets insiders pre-schedule sales weeks or months in advance. These sales execute on a fixed plan regardless of company news, so they're a weaker signal than discretionary sales. We label them with a "10b5-1" tag.

What is an insider cluster?

A cluster is when three or more distinct insiders buy or sell within a 14-day window. Clusters are studied as stronger signals than single trades because multiple people independently reach the same view. We surface active clusters on Spyre Therapeutics, Inc. (SYRE) when they form.

Where does SYRE insider trading data come from?

Every Form 4 filing for SYRE is sourced directly from SEC EDGAR. Tracenotes scans EDGAR daily, parses each Form 4 into individual transactions, and updates this page within hours of new filings.

Nothing on this page constitutes investment advice. Form 4 data is sourced from SEC EDGAR and provided for research purposes only.

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