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AMLX Insider Trading & Form 4 Activity

Amylyx Pharmaceuticals, Inc.
Last filing: Oct 7, 2026·17 days ago
BEARISH · LAST 90 DAYS
0%
buyers
$0
0 buys
$2.9M
10 sells
-$2.9M
net selling
5
insiders
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ACTIVE SELLING CLUSTER

5 insiders sold a combined $2.9M of AMLX on Sep 10, 2026.

Bedrosian Camille L, Mazzariello Gina, Cohen Joshua B, Frates James M, Klee Justin B.

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Net flow — last 12 months

Monthly net of insider buys minus sells. Green months indicate net buying; red months indicate net selling.

Most active insiders

Ranked by total transaction value over the last 90 days.

INSIDERBOUGHTSOLDNET
Cohen Joshua B
Co-Chief Executive Officer
—
$981K
-$981K
Klee Justin B.
Co-Chief Executive Officer
—
$980K
-$980K
Milne George M JR
Director
—
$831K
-$831K
Frates James M
Chief Financial Officer
—
$350K
-$350K
Bedrosian Camille L
Chief Medical Officer
—
$325K
-$325K
Mazzariello Gina
Chief Legal Officer
—
$310K
-$310K
Firestone Karen
Director
—
—
$0

Recent transactions

Every Form 4 transaction for AMLX, newest first.

SELL10b5-1
Milne George M JR · Director
Tx Oct 5·Filed Oct 7·EDGAR ↗
30,000 sh @ $27.70
$831K
SELL
Bedrosian Camille L · Chief Medical Officer
Tx Sep 10·Filed Sep 14·EDGAR ↗
2,081 sh @ $33.09
$69K
SELL
Bedrosian Camille L · Chief Medical Officer
Tx Sep 10·Filed Sep 14·EDGAR ↗
7,947 sh @ $32.21
$256K
SELL
Mazzariello Gina · Chief Legal Officer
Tx Sep 10·Filed Sep 14·EDGAR ↗
9,525 sh @ $32.46
$309K
SELL
Mazzariello Gina · Chief Legal Officer
Tx Sep 10·Filed Sep 14·EDGAR ↗
11 sh @ $33.34
$367
SELL
Cohen Joshua B · Co-Chief Executive Officer
Tx Sep 10·Filed Sep 14·EDGAR ↗
29,545 sh @ $32.16
$950K
SELL
Cohen Joshua B · Co-Chief Executive Officer
Tx Sep 10·Filed Sep 14·EDGAR ↗
919 sh @ $33.15
$30K
SELL
Frates James M · Chief Financial Officer
Tx Sep 10·Filed Sep 14·EDGAR ↗
9,768 sh @ $32.27
$315K
SELL
Frates James M · Chief Financial Officer
Tx Sep 10·Filed Sep 14·EDGAR ↗
1,042 sh @ $33.23
$35K
SELL
Klee Justin B. · Co-Chief Executive Officer
Tx Sep 10·Filed Sep 14·EDGAR ↗
29,025 sh @ $32.13
$933K
SELL
Klee Justin B. · Co-Chief Executive Officer
Tx Sep 10·Filed Sep 14·EDGAR ↗
1,439 sh @ $33.16
$48K
EXERCISE
Firestone Karen · Director
Tx Aug 31·Filed Sep 2·EDGAR ↗
25,000 sh @ $1.76
$44K
AWARD
Bedrosian Camille L · Chief Medical Officer
Tx Aug 18·Filed Aug 20·EDGAR ↗
22,807 sh
—
AWARD
Cohen Joshua B · Co-Chief Executive Officer
Tx Aug 18·Filed Aug 20·EDGAR ↗
60,039 sh
—
AWARD
Frates James M · Chief Financial Officer
Tx Aug 18·Filed Aug 20·EDGAR ↗
22,807 sh
—
AWARD
Klee Justin B. · Co-Chief Executive Officer
Tx Aug 18·Filed Aug 20·EDGAR ↗
60,039 sh
—
AWARD
Mazzariello Gina · Chief Legal Officer
Tx Aug 18·Filed Aug 20·EDGAR ↗
21,284 sh
—
SELL10b5-1
Mazzariello Gina · Chief Legal Officer
Tx Jul 10·Filed Jul 13·EDGAR ↗
15,000 sh @ $17.61
$264K
SELL10b5-1
Mazzariello Gina · Chief Legal Officer
Tx Jul 9·Filed Jul 13·EDGAR ↗
15,000 sh @ $18.32
$275K
BUY
Firestone Karen · Director
Tx May 21·Filed May 26·EDGAR ↗
3,800 sh @ $13.51
$51K

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About AMLX insider trading data

Form 4 is the SEC filing required when an officer, director, or 10% owner of a public company buys or sells the company's stock. By law, these filings must be submitted within two business days of the trade. Tracenotes pulls every Form 4 filing for AMLX from EDGAR, parses it, and surfaces the activity on this page.

What insider buying tells you. Open-market purchases by insiders are widely studied as a meaningful signal. Unlike stock awards (which are compensation, not conviction), an executive spending their own money to buy shares of the company they run is a vote of confidence. Studies have found insider-buying clusters — three or more insiders buying within a short window — outperform the broader market over the following year.

What insider selling tells you. Selling is noisier. Many sales are pre-scheduled under SEC Rule 10b5-1 plans, which let insiders sell on a fixed schedule regardless of company news. We label these "10b5-1" so you can see them. Discretionary sales — sales not tied to a plan — are more meaningful, especially when multiple insiders sell in quick succession.

Tracenotes methodology. We scan EDGAR daily for new Form 4 filings, parse them into individual transactions, and detect clusters when three or more distinct insiders buy or sell within a 14-day window. The data on this page covers the last 12 months. For deeper analysis, Tracenotes also runs language-change detection on 10-K and 10-Q filings — that's our core product.

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Frequently asked questions

What is a Form 4 filing?

Form 4 is the SEC disclosure required when a company insider — an officer, director, or 10% owner — buys or sells the company's stock. By law these filings must be submitted within two business days of the trade.

Is insider buying AMLX always bullish?

Open-market purchases by insiders are widely viewed as a bullish signal because executives are spending their own money. Stock awards and option exercises are part of compensation and don't carry the same weight, which is why we treat them separately on this page.

What is a 10b5-1 trade?

A trade made under SEC Rule 10b5-1, which lets insiders pre-schedule sales weeks or months in advance. These sales execute on a fixed plan regardless of company news, so they're a weaker signal than discretionary sales. We label them with a "10b5-1" tag.

What is an insider cluster?

A cluster is when three or more distinct insiders buy or sell within a 14-day window. Clusters are studied as stronger signals than single trades because multiple people independently reach the same view. We surface active clusters on Amylyx Pharmaceuticals, Inc. (AMLX) when they form.

Where does AMLX insider trading data come from?

Every Form 4 filing for AMLX is sourced directly from SEC EDGAR. Tracenotes scans EDGAR daily, parses each Form 4 into individual transactions, and updates this page within hours of new filings.

Nothing on this page constitutes investment advice. Form 4 data is sourced from SEC EDGAR and provided for research purposes only.

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